Results 91 to 100 of about 1,634,541 (309)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

EVALUASI DAN PENGEMBANGAN JARINGAN DISTRIBUSI AIR BERSIH DI KECAMATAN TUREN KABUPATEN MALANG [PDF]

Clean water is a basic need for society, but the distribution of clean water in Turen District, Malang Regency still faces several problems. This research aims to evaluate the condition of the clean water distribution network and propose development ...
Olviyani, Mustikarina
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Demanda de irrigação da cultura da uva na Bacia do Rio São Francisco Irrigation demand for grape crop in San Francisco River Basin

Revista Brasileira de Engenharia Agrícola e Ambiental, 2006
Visando subsidiar o planejamento de projetos agrícolas para o dimensionamento de projetos de irrigação e a gestão de recursos hídricos, estimou-se e se espacializou a demanda de irrigação da videira (Vitis vinifera L.), cv.
Wallisson da S. Freitas, Márcio M. Ramos, Ângelo M. S Oliveira   +2 more
doaj   +1 more source

Tropospheric Phase Calibration in Millimeter Interferometry

, 1999
We review millimeter interferometric phase variations caused by variations in the precipitable water vapor content of the troposphere, and we discuss techniques proposed to correct for these variations.
Asaki, Asaki, Bean, Bremer, C. L. Carilli, Clark, Cornwell, Coulman, Coulman, Dicke, Drashkik, Ekers, Elgered, Elgered, Fomalont, Garratt, Hinder, Hogg, Kutner, Lay, Lay, Liebe, Lim, Linfield, M. A. Holdaway, Marvel, Napier, Rosenkranz, Rosenkranz, Staelin, Staguhn, Sutton, Tatarskii, Thompson, Treuhaft, Waters, Welch, Westwater, Wilner, Wright, Zheng   +40 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Effect of Deficit Irrigation and Regulated Deficit Irrigation on Yield and Water Productivity of the Watermelon [PDF]

مجله آب و خاک
Introduction Watermelon (Citrullus lanatus) is a widely recognized product with high demand, nutritional value, and export potential worldwide. Since the ultimate goal of agricultural production systems is to maximize plant yield, providing sufficient ...
N. Bahremand, H. Aroiee, A. Aien
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Teknologi Pengolahan Air Siap Minum Untuk Daerah Padat Penduduk [PDF]

, 2005
One of common problem on dense settlement area in Indonesia is the need for clean water and especially at rural and isolated areas this problem have not been properly solved yet.
Widayat, W. (Wahyu)
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source