Results 61 to 70 of about 1,634,989 (241)

Statement to Water Resources Subcommittee of House Committee on Public Works and Transportation for a Hearing, May 24 and 25, 1978, Washington, D.C. regarding Secondary Treatment Waivers and Ocean Outfalls [PDF]

open access: yes, 1978
The principal technical reason for having a waiver provision for secondary treatment for municipal discharges is that for some outfall systems the dilution is so high that very good ambient water quality can be achieved with less than secondary ...
Brooks, Norman H.
core  

Tropospheric Phase Calibration in Millimeter Interferometry

open access: yes, 1999
We review millimeter interferometric phase variations caused by variations in the precipitable water vapor content of the troposphere, and we discuss techniques proposed to correct for these variations.
Asaki   +40 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Improved fire-resistant coatings [PDF]

open access: yes, 1971
Water-base coatings containing potassium silicate show improvement in areas of quick air-drying, crack, craze, and abrasion resistance, adherence, and leach resistance.
Hutt, J. B., Stuart, J. W.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

A Method for the Rapid Cultivation of Desulfovibrio aestuarii on Filter Membranes [PDF]

open access: yes, 1958
The cultivation of sulfate-reducing bacteria on agar plates is a somewhat involved and time-consuming process. This is partly due to the requirement for fairly strict anaerobic conditions but mainly because of the length of the incubation period which ...
Goetz, A., Tsuneishi, N.
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Effects of crop evapotranspiration estimation techniques and weather parameters on rice crop water requirement [PDF]

open access: yes, 2014
Accurate estimation of crop evapotranspiration is key to determination of crop water requirements as well as water productivity. In this study, Microflex-C sensors were mounted on three sets of lysimeter to measure crop evapotranspiration in the paddy ...
Abd Aziz, Samsuzana   +5 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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