Results 101 to 110 of about 1,201,661 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A three-dimensional linear analysis of steady ship motion in deep water

, 1986
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The investigation of steady ship motion in calm water is a classic problem in ship hydrodynamics, where ship waves and wave resistance are subjects of ...
Baar, J.M, Baar, Job
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Evaporation and Soil Surface Resistance of the Water Storage Pit Irrigation Trees in the Loess Plateau

, 2019
As an important step for formulating a water-saving agricultural strategy, it is essential to make quantitative calculations for orchard soil evaporation and confirm its inner mechanism, so as to reduce ineffective water consumption and improve the ...
Xihuan Sun, Juanjuan Ma, Wei Meng, Lijian Zheng, Xianghong Guo   +4 more
core   +1 more source

Antimicrobial resistance and virulence determinants in European Salmonella genomic island 1-positive Salmonella enterica isolates from different origins. [PDF]

, 2011
Salmonella genomic island 1 (SGI1) contains a multidrug resistance region conferring the ampicillin-chloramphenicol-streptomycin-sulfamethoxazole-tetracycline resistance phenotype encoded by bla(PSE-1), floR, aadA2, sul1, and tet(G).
Hauser, E., Dep Infectieziekten Immunologie, Advances in Veterinary Medicine, Beutlich, Janine, Rodicio, M. R., Schroeter, A., Threlfall, J., Med-Vet-Net WP21 Project Group, Janine Beutlich, Bernd Appel, Malorny, B., Trelfall, J., Andreas Schroeter, Malorny, Burkhard, Thelfall, J., Helmuth, R., Jahn, S., Burkhard Malorny, Elisabeth Hauser, Reiner Helmuth, Stephan Hühn, Dik Mevius, Beatriz Guerra, Mevius, D.J., Rodicio, M.R., Maria Rosario Rodicio, Jahn, Silke, John Threlfall, Appel, B., Rodicio Rodicio, María del Rosario, Silke Jahn, Hühn, S., Mevius, D., Beutlich, J., Rosario Rodicio, M., Guerra, B.   +35 more
core   +1 more source

Production of glass-alkali binder for construction purposes by recycling of cullet

Magazine of Civil Engineering
Municipal solid waste poses significant environmental challenges due to its wide range and po-tential contaminating impact. Finding sustainable solutions for its disposal is imperative.
Prisyazhnyuk Anastasia, Vorontsov Victor
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The effect of free chlorine on Burkholderia pseudomallei in potable water

, 2003
Chlorine is widely used in public water supplies to provide a disinfection barrier. The effect of chlorine disinfection on the water-borne pathogen Burkholderia pseudomallei was assessed using multiple techniques.
Howard, K., Inglis, T.J.J.
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mutability and survival of pseudomonas aeruginosa in multi-species drinking water biofilm communities

, 2012
Pseudomonas aeruginosa is an important opportunistic pathogen of humans and also has the ability to form biofilms in drinking water. However, the survival, persistence and the control of this pathogen within mixed-species bacterial communities in ...
Kennedy, Enyioha
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