Results 31 to 40 of about 161,767 (285)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Assessment of Forty-Five Bambara Groundnut (Vigna subterranea) Accessions Under Varying Environments in Kenya Using Morphological and Yield Components

International Journal of Agronomy
Understanding the agromorphological diversity of Bambara groundnut is crucial in enhancing its adaptability and productivity in Kenya, where production is localized to a few areas.
Mercy Chelangat, Bernard M. Gichimu, Phyllis W. Muturi, Josiah N. Gitari   +3 more
doaj   +1 more source

Modeling the spatio-temporal flow dynamics of groundwater-surface water interactions of the Lake Tana Basin, Upper Blue Nile, Ethiopia

Hydrology Research, 2020
The Ethiopian government has selected Lake Tana basin as a development corridor due to its water resources potential. However, combined use of groundwater (GW) and surface water (SW) is still inadequate due to knowledge gaps about the flow dynamics of GW
Tibebe B. Tigabu, Paul D. Wagner, Georg Hörmann, Nicola Fohrer   +3 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Modified Climate-Smart Push-Pull Technology for the Management of Fall Armyworm (Spodoptera frugiperda) in the Semiarid Lands of Kenya

International Journal of Agronomy
Successful use of push-pull technology in the control of fall armyworm (Spodoptera frugiperda Smith) in maize has been limited to areas that receive optimal rainfall as opposed to the semiarid areas.
Catherine K. Mumo, Phyllis W. Muturi, Bernard M. Gichimu   +2 more
doaj   +1 more source

Re-suspension of bed sediment in a small stream – results from two flushing experiments [PDF]

Hydrology and Earth System Sciences, 2014
Streams draining small watersheds often exhibit multiple peaking sedigraphs associated with single peaking hydrographs. The process reasons of the multiple sediment peaks are not fully understood but they may be related to the activation of different ...
A. Eder, M. Exner-Kittridge, P. Strauss, G. Blöschl   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effects of land cover, topography, and soil on stream water quality at multiple spatial and seasonal scales in a German lowland catchment

Ecological Indicators, 2021
The influence of catchment characteristics on water quality varies with space and time. Understanding the key factors influencing water quality is needed for effective land use and riparian management to protect river health.
Chaogui Lei, Paul D. Wagner, Nicola Fohrer   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source