Results 21 to 30 of about 3,684,192 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Sensitivity of Winter Wheat to Drought Occurring at Different Growth Stages

Guan'gai paishui xuebao, 2021
【Background and objective】 Sensitivity of crop to drought is a measure of the response of its growth and yield to water stress occurring at different growth stages.
XU Hu, JIANG Shangming, YUAN Hongwei, LIU Jia, JIN Juliang   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Water resources

, 2015
Outgoing
Thomas Rauschenbach, Albrecht Gnauck, Oliver Krol, Thomas Bernard, Torsten Pfützenreuter   +4 more
  +5 more sources

Spatio-temporal characterization of drought variability in data-scarce regions using global precipitation data: a case study in Cauto river basin, Cuba

Scientific Reports
Drought is considered the most severe water-related disaster in the Cauto river basin, which is the longest river and the main agricultural producer in Cuba. Better understanding of drought characteristics is crucial to drought management.
Anh Phuong Tran, Bao Chung Tran, Siliennis Blanco Campbell, Nam Anh Nguyen, Dieu Hang Tran, Thanh Thuy Nguyen, Anh Duc Nguyen, Hong Son Duong   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Risk Assessment of Yellow Muddy Water in High-Construction-Intensity Cities Based on the GIS Analytic Hierarchy Process Method: A Case Study of Guangzhou City

Land
During urbanisation, extensive production and construction activities encroach on ecological spaces, leading to changes in environmental structures and soil erosion.
Xichun Jia, Xuebing Jiang, Jun Huang, Le Li, Bingjun Liu, Shunchao Yu   +5 more
doaj   +1 more source

Study on reservoir optimal operation based on coupled adaptive ε constraint and multi strategy improved Pelican algorithm

Scientific Reports, 2023
The optimal operation of reservoir groups is a strongly constrained, multi-stage, and high-dimensional optimization problem. In response to this issue, this article couples the standard Pelican optimization algorithm with adaptive ε constraint methods ...
Ji He, Xiaoqi Guo, Songlin Wang, Haitao Chen, Fu-Xin Chai   +4 more
doaj   +1 more source

Water quality assessment, trophic classification and water resources management [PDF]

, 2010
Quantification of water quality (WQ) is an integral part of scientifically based water resources management. The main objective of this study was comparative analysis of two approaches applied for quantitative assessment of WQ: the trophic level index ...
Gal, Gideon, Hamilton, David P., Kasprzak, Peter, Ostapenia, Alexandr, Parparov, Arkadi   +4 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source