Results 41 to 50 of about 1,035,406 (257)

A Coupled Model for Forecasting Spatiotemporal Variability of Regional Drought in the Mu Us Sandy Land Using a Meta-Heuristic Algorithm

Land
Vegetation plays a vital role in terrestrial ecosystems, and droughts driven by rising temperatures pose significant threats to vegetation health.
Changfu Tong, Hongfei Hou, Hexiang Zheng, Ying Wang, Jin Liu   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Time lag effect of precipitation on groundwater level based on wavelet analysis in the People’s Victory Canal irrigation area, China

Scientific Reports
The People’s Victory Canal irrigation area is an important agricultural irrigation region in the North China Plain, where groundwater resources play a crucial role in both agricultural production and the ecological environment.
Zhongpei Liu, Xiaoqing Li, Zhipeng Hu, Runxiang Cao, Yuping Han, Lin Wu   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Hybrid framework for robust runoff forecasting via decomposition and machine learning

Scientific Reports
Accurate runoff forecasting is essential for flood control and water resource management, yet strong nonlinearity and seasonal non-stationarity often limit traditional models. This study proposes a hybrid decomposition-integration-optimization framework (
Wen-chuan Wang, Xu-tong Zhang, Qi-qi Zeng, Hong-zhen Ren, Dong-mei Xu, Qiang Ma   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Simulation and analysis of evapotranspiration from desert grasslands based on a random forest regression model

Scientific Reports
Evapotranspiration (ET) is a critical component of the water and energy cycles in desert grassland ecosystems. However, modeling ET in arid grasslands faces significant challenges due to data scarcity, high spatiotemporal heterogeneity, and complex ...
Haitao Chen, Nishi Chu, Aiqing Kang, Wenchuan Wang, Ji He   +4 more
doaj   +1 more source

Evaluating the Patterns of Maize Development in the Hetao Irrigation Region Using the Sentinel-1 GRD SAR Bipolar Descriptor

Sensors
Assessing maize yield is critical, as it is directly influenced by the crop’s growth conditions. Therefore, real-time monitoring of maize growth is necessary. Regular monitoring of maize growth indicators is essential for optimizing irrigation management
Hexiang Zheng, Hongfei Hou, Delong Tian, Changfu Tong, Ziyuan Qin   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Research on Water and Fertilizer Use Strategies for Silage Corn Under Different Irrigation Methods to Mitigate Abiotic Stress

Plants
To reconcile the intensifying trade-off between chronic water scarcity and escalating forage demand in the Yellow River Basin, this study optimized integrated irrigation and fertilization regimes for silage maize. Leveraging the AquaCrop model, validated
Delong Tian, Yuchao Chen, Bing Xu, Guoshuai Wang, Lingyun Xu   +4 more
doaj   +1 more source