Results 51 to 60 of about 1,277,146 (271)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Time lag effect of precipitation on groundwater level based on wavelet analysis in the People’s Victory Canal irrigation area, China

Scientific Reports
The People’s Victory Canal irrigation area is an important agricultural irrigation region in the North China Plain, where groundwater resources play a crucial role in both agricultural production and the ecological environment.
Zhongpei Liu, Xiaoqing Li, Zhipeng Hu, Runxiang Cao, Yuping Han, Lin Wu   +5 more
doaj   +1 more source

A Coupled Model for Forecasting Spatiotemporal Variability of Regional Drought in the Mu Us Sandy Land Using a Meta-Heuristic Algorithm

Land
Vegetation plays a vital role in terrestrial ecosystems, and droughts driven by rising temperatures pose significant threats to vegetation health.
Changfu Tong, Hongfei Hou, Hexiang Zheng, Ying Wang, Jin Liu   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hybrid framework for robust runoff forecasting via decomposition and machine learning

Scientific Reports
Accurate runoff forecasting is essential for flood control and water resource management, yet strong nonlinearity and seasonal non-stationarity often limit traditional models. This study proposes a hybrid decomposition-integration-optimization framework (
Wen-chuan Wang, Xu-tong Zhang, Qi-qi Zeng, Hong-zhen Ren, Dong-mei Xu, Qiang Ma   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Simulation and analysis of evapotranspiration from desert grasslands based on a random forest regression model

Scientific Reports
Evapotranspiration (ET) is a critical component of the water and energy cycles in desert grassland ecosystems. However, modeling ET in arid grasslands faces significant challenges due to data scarcity, high spatiotemporal heterogeneity, and complex ...
Haitao Chen, Nishi Chu, Aiqing Kang, Wenchuan Wang, Ji He   +4 more
doaj   +1 more source

Evaluating the Patterns of Maize Development in the Hetao Irrigation Region Using the Sentinel-1 GRD SAR Bipolar Descriptor

Sensors
Assessing maize yield is critical, as it is directly influenced by the crop’s growth conditions. Therefore, real-time monitoring of maize growth is necessary. Regular monitoring of maize growth indicators is essential for optimizing irrigation management
Hexiang Zheng, Hongfei Hou, Delong Tian, Changfu Tong, Ziyuan Qin   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research on Water and Fertilizer Use Strategies for Silage Corn Under Different Irrigation Methods to Mitigate Abiotic Stress

Plants
To reconcile the intensifying trade-off between chronic water scarcity and escalating forage demand in the Yellow River Basin, this study optimized integrated irrigation and fertilization regimes for silage maize. Leveraging the AquaCrop model, validated
Delong Tian, Yuchao Chen, Bing Xu, Guoshuai Wang, Lingyun Xu   +4 more
doaj   +1 more source