Results 61 to 70 of about 12,262,922 (372)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Coupled Model for Forecasting Spatiotemporal Variability of Regional Drought in the Mu Us Sandy Land Using a Meta-Heuristic Algorithm

Land
Vegetation plays a vital role in terrestrial ecosystems, and droughts driven by rising temperatures pose significant threats to vegetation health.
Changfu Tong, Hongfei Hou, Hexiang Zheng, Ying Wang, Jin Liu   +4 more
doaj   +1 more source

Gainers and losers of surface and terrestrial water resources in China during 1989–2016

Nature Communications, 2020
Data and knowledge of the spatial-temporal dynamics of surface water area (SWA) and terrestrial water storage (TWS) in China are critical for sustainable management of water resources but remain very limited.
Xinxin Wang, Xiangming Xiao, Z. Zou, Jinwei Dong, Yuanwei Qin, R. Doughty, M. Menarguez, Bangqian Chen, Jun-bang Wang, H. Ye, Jun Ma, Qiao-Yan Zhong, Bin Zhao, Bo Li   +13 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evaluating the Patterns of Maize Development in the Hetao Irrigation Region Using the Sentinel-1 GRD SAR Bipolar Descriptor

Sensors
Assessing maize yield is critical, as it is directly influenced by the crop’s growth conditions. Therefore, real-time monitoring of maize growth is necessary. Regular monitoring of maize growth indicators is essential for optimizing irrigation management
Hexiang Zheng, Hongfei Hou, Delong Tian, Changfu Tong, Ziyuan Qin   +4 more
doaj   +1 more source

Winter melt trends portend widespread declines in snow water resources

Nature Climate Change, 2020
In many mountainous regions, winter precipitation accumulates as snow that melts in the spring and summer, which provides water to one billion people globally. Climate warming and earlier snowmelt compromise this natural water storage.
K. Musselman, N. Addor, J. Vano, N. Molotch   +3 more
semanticscholar   +1 more source

Water resources management in a homogenizing world: Averting the Growth and Underinvestment trajectory [PDF]

, 2014
Biotic homogenization, a de facto symptom of a global biodiversity crisis, underscores the urgency of reforming water resources management to focus on the health and viability of ecosystems.
Hjorth, P, Huckins, CJ, Madani, K, Mirchi, A, Watkins, DW   +4 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Time lag effect of precipitation on groundwater level based on wavelet analysis in the People’s Victory Canal irrigation area, China

Scientific Reports
The People’s Victory Canal irrigation area is an important agricultural irrigation region in the North China Plain, where groundwater resources play a crucial role in both agricultural production and the ecological environment.
Zhongpei Liu, Xiaoqing Li, Zhipeng Hu, Runxiang Cao, Yuping Han, Lin Wu   +5 more
doaj   +1 more source

Research on Water and Fertilizer Use Strategies for Silage Corn Under Different Irrigation Methods to Mitigate Abiotic Stress

Plants
To reconcile the intensifying trade-off between chronic water scarcity and escalating forage demand in the Yellow River Basin, this study optimized integrated irrigation and fertilization regimes for silage maize. Leveraging the AquaCrop model, validated
Delong Tian, Yuchao Chen, Bing Xu, Guoshuai Wang, Lingyun Xu   +4 more
doaj   +1 more source