Results 61 to 70 of about 3,597,926 (326)

Evaluating the Patterns of Maize Development in the Hetao Irrigation Region Using the Sentinel-1 GRD SAR Bipolar Descriptor

Sensors
Assessing maize yield is critical, as it is directly influenced by the crop’s growth conditions. Therefore, real-time monitoring of maize growth is necessary. Regular monitoring of maize growth indicators is essential for optimizing irrigation management
Hexiang Zheng, Hongfei Hou, Delong Tian, Changfu Tong, Ziyuan Qin   +4 more
doaj   +1 more source

Water Demand Forecast in the Baiyangdian Basin with the Extensive and Low-Carbon Economic Modes

Journal of Applied Mathematics, 2014
The extensive and low-carbon economic modes were constructed on the basis of population, urbanization level, economic growth rate, industrial structure, industrial scale, and ecoenvironmental water requirement.
T. L. Qin, D. H. Yan, G. Wang, J. Yin
doaj   +1 more source

Water resources management in a homogenizing world: Averting the Growth and Underinvestment trajectory [PDF]

, 2014
Biotic homogenization, a de facto symptom of a global biodiversity crisis, underscores the urgency of reforming water resources management to focus on the health and viability of ecosystems.
Hjorth, P, Huckins, CJ, Madani, K, Mirchi, A, Watkins, DW   +4 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Time lag effect of precipitation on groundwater level based on wavelet analysis in the People’s Victory Canal irrigation area, China

Scientific Reports
The People’s Victory Canal irrigation area is an important agricultural irrigation region in the North China Plain, where groundwater resources play a crucial role in both agricultural production and the ecological environment.
Zhongpei Liu, Xiaoqing Li, Zhipeng Hu, Runxiang Cao, Yuping Han, Lin Wu   +5 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Simulation and analysis of evapotranspiration from desert grasslands based on a random forest regression model

Scientific Reports
Evapotranspiration (ET) is a critical component of the water and energy cycles in desert grassland ecosystems. However, modeling ET in arid grasslands faces significant challenges due to data scarcity, high spatiotemporal heterogeneity, and complex ...
Haitao Chen, Nishi Chu, Aiqing Kang, Wenchuan Wang, Ji He   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Minimal-time bioremediation of natural water resources [PDF]

, 2011
We study minimal time strategies for the treatment of pollution of large volumes, such as lakes or natural reservoirs, with the help of an autonomous bioreactor. The control consists in feeding the bioreactor from the resource, the clean output returning
Cabrera, Hector Ramirez, Gajardo, Pedro, Harmand, Jérôme, Rapaport, Alain   +3 more
core   +5 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source