Results 71 to 80 of about 3,548,030 (339)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Study on Alfalfa Water Use Efficiency and Optimal Irrigation Strategy in Agro-Pastoral Ecotone, Northwestern China

Agronomy
Agro-pastoral ecotone is an important livestock production area in the north of China, and alfalfa is the main pasture crop in this area. Aiming to address the issues of groundwater overexploitation in the area with water demand, we assessed the ...
Xiangyang Miao, Guoshuai Wang, Bing Xu, Ruiping Li, Delong Tian, Jie Ren, Zekun Li, Ting Fan, Zisen Zhang, Qiyu Xu   +9 more
doaj   +1 more source

Alaskan water resources: Selected abstracts, 1974 [PDF]

, 1977
Compiled and Edited by Charles Hartman and Sheila. FinchAs one of the 51 Water Resources Research Institutes administered under the Water Resources Research Act of 1964, IWR receives a semimonthly journal entitled Selected Water Resources Abstracts.
Finch, Sheila, Hartman, Charles
core  

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Simulation of Maize Growth Under the Applications of Brackish Water in Northwest China

Agronomy
The objective of this study is to assess the suitability of the AquaCrop model for growing maize using brackish water irrigation in Northwest China. Additionally, this study aims to examine how maize utilizes water in various soil layers when irrigated ...
Changfu Tong, Rui He, Jun Wang, Hexiang Zheng   +3 more
doaj   +1 more source

Water Resources [PDF]

Water resources survey, management, and control by means of ERTS-1 data ...
Rango, A., Salomonson, V. V.
core   +4 more sources

Arkansas Water Resources Research Center Pamphlet [PDF]

, 1990
Arkansas Water Resources Center (AWRC) works closely with state and federal agencies and academic institutions. Priority research categories are: surface water analysis, ground water pollution, surface and ground water quality/quanity, and water resource
Steele, Kenneth F.
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Arkansas Water Resources Research Center Pamphlet [PDF]

, 1985
Arkansas Water Resources Research Center (AWRRC), through research is committed to meeting the many and varied challenges presented to water quality by Arkansas\u27 burgeoning urban, agricultural, and recreational water ...
Meyer, Richard L.
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source