Results 41 to 50 of about 1,897,800 (323)
Advances in Meteorology, 2022 Climate changes significantly cause the precipitation deficiency and in turn reduce the inflow amount in reservoir affecting hydroelectric power generation. The primary objective of this study was to evaluate hydropower generation and reservoir operation
Kinfe Bereda Mirani +3 more
doaj +1 more source
Water resources development: engineering the future of global health [PDF]
, 2013 This repository item contains a single issue of Issues in Brief, a series of policy briefs that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.Pardee 2012 Summer Graduate Fellow Diana
Gergel, Diana
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Is there progress in the adsorbent development for water treatment?
iScienceSummary: Adsorption technology is an essential part of modern water treatment. However, only a handful of adsorbent materials are used industrially, which is in striking contrast with the exponentially increasing scientific publishing activity.
Tero Luukkonen, Juhani Teeriniemi
doaj +1 more source
Effects of precipitation and potential evaporation on actual evapotranspiration over the Laohahe basin, northern China [PDF]
Proceedings of the International Association of Hydrological Sciences, 2015 Problems associated with water scarcity are facing new challenges under the climate change. As one of main consumptions in water cycle on the Earth, evapotranspiration plays a crucial role in regional water budget. In this paper, we employ two methods,
Y. Liu +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Soil and Water Research, 2009 The hydrologic adversaries like high magnitude storms, extreme dryness, aridity, more than normal demand for water etc. often cause a huge stress on the storage structures such as reservoirs and check dams. This stress implies a lot of adverse effects on
Mrinmoy Majumder +4 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Scientific Reports, 2021 A population exceeding 3.8 million people in the western region of 24-Parganas (South) is directly or indirectly reliant on agriculture as their primary source of livelihood.
Prasun Mukherjee +2 more
doaj +1 more source