Results 181 to 190 of about 346,500 (295)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Illinois Water and Climate Summary, 2000

open access: yes, 2000
Open Restriction set for Item 105657 on 2018-04-17T14:49:32Z with date null by sheppard@illinois.edu.Submitted by Lisa Sheppard (sheppard@illinois.edu) on 2018-04-17T14:56:27Z No.
Water and Atmospheric Resource Monitoring Program
core  

Salicylic acid improves cowpea productivity under water restriction in the field by modulating metabolism. [PDF]

open access: yesFront Plant Sci
Cavalcante IE   +10 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Illinois Water and Climate Summary, 2015

open access: yes, 2015
Open Restriction set for Item 105655 on 2018-04-16T21:21:29Z with date null by sheppard@illinois.edu.Submitted by Lisa Sheppard (sheppard@illinois.edu) on 2018-04-16T21:38:24Z No.
Water and Atmospheric Resource Monitoring Program
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Illinois Water and Climate Summary, 2014

open access: yes, 2014
Open Restriction set for Item 105650 on 2018-04-16T20:56:44Z with date null by sheppard@illinois.edu.Submitted by Lisa Sheppard (sheppard@illinois.edu) on 2018-04-16T21:19:39Z No.
Water and Atmospheric Resource Monitoring Program
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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