Results 81 to 90 of about 957,139 (290)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Multi-year Water Allocation: A Policy Analysis for Groundwater Management and Conservation for Irrigated Agriculture [PDF]

Heavy withdrawals from the most dependable source of groundwater in the Texas Panhandle, the Ogallala Aquifer, create an impending need for implementing water conservation policies.
Almas, Lal K., Lust, David G., Tewari, Rachna   +2 more
core   +1 more source

Effect of Restricted Water Consumption on Broiler Chickens

Poultry Science, 1965
Abstract CHICKENS cannot survive very long when deprived of water. A ten percent loss of body water through dehydration and excretion results in serious physical disorders (Romanoff and Romanoff, 1949). Dehydration is particularly noticeable in the shanks, and some mortality may result as reported by Marble and Jeffrey (1955).
S U, KELLERUP, J E, PARKER, G H, ARSCOTT
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Proposing a strategy based on body-thermal status to improve the welfare of heat-stressed and water-deprived goats () [PDF]

Animal Bioscience
Objective Despite the considerable body of research on the effects of heat stress coupled with water scarcity (either through restriction or deprivation) on goats, aimed at enhancing their welfare, there remains a notable gap in the literature regarding ...
Emad M. Samara, Mohammed A. Al-Badwi, Khalid A. Abdoun, Ahmed A. Al-Haidary   +3 more
doaj   +1 more source

The contribution of differential hatching success to the fitness of species and interspecific hybrids [PDF]

, 2007
Resting egg banks of microcrustaceans have been used to reconstruct the evolutionary and ecological history of species. However, recent studies provided evidence for a discrepancy between dormant propagules in the sediment and the planktonic population ...
Brede, Nora, Schwenk, Klaus, Straile, Dietmar, Streit, Bruno   +3 more
core   +1 more source

WATER ACTIVITY RESTRICTION BY APPLICATION OF ESSENTIALS OILS

Cellulose Chemistry and Technology, 2019
The antimicrobial activity of essential oils (EO) is mainly connected to the restriction of water distribution in reticular porous systems of bioactive matters, but the whole process is more complex. The reversibility of the EO desorption process in the water vapour environment of porous lignocellulosic materials, such as paper, is mainly controlled by
Milichovský, Miloslav, Češek, Břetislav, Mikala, Ondřej, Gojný, Jan   +3 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transmissibilidade e efeito de Acremonium strictum em sementes de milho Transmissibility and effect of Acremonium strictum in maize seeds

Ciência e Agrotecnologia, 2003
Acremonium strictum é patogênico ao milho e a outras culturas, podendo causar podridão de sementes, podridão de colmos e a morte de plântulas. Trata-se de um fungo que pode interferir no vigor, estande e produtividade final das plantas.
Hudson Teixeira, José da Cruz Machado
doaj   +1 more source