Results 81 to 90 of about 346,500 (295)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Proposing a strategy based on body-thermal status to improve the welfare of heat-stressed and water-deprived goats () [PDF]

Animal Bioscience
Objective Despite the considerable body of research on the effects of heat stress coupled with water scarcity (either through restriction or deprivation) on goats, aimed at enhancing their welfare, there remains a notable gap in the literature regarding ...
Emad M. Samara, Mohammed A. Al-Badwi, Khalid A. Abdoun, Ahmed A. Al-Haidary   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Modelling bounce-back in water consumption post-drought

, 2013
Focused on a case study of Geelong, Victoria, this paper presents the results of a unique comparison of (i) a custombuilt regression model for forecasting total customer water demand and (ii) end-use based water projections using the integrated Supply ...
Teng, ML, Mohr, SH, Giurco, D, Franklin, J, Fyfe, J, Rickwood, P   +5 more
core  

Impact of water restriction periods on carcass traits and meat quality of feedlot lambs in the Brazilian semi-arid region. [PDF]

, 2019
Water restriction periods were evaluated in crossbred lambs (n=32) distributed in one of four treatments: without water restriction, water restriction for 24, 48 and 72 h.
QUEIROZ, M. A. A., Santos, Fernanda Maria dos, Souza, Larissa Lopes de, ARAUJO, G. G. L. de, Fernanda Maria dos Santos, Larissa Lopes de Souza, SANTOS, F. M. dos, Salete Alves de Moraes, YAMAMOTO, S. M., Leal de Araujo, Gherman Garcia, Avila Queiroz, Mario Adriano, Sandra Mari Yamamoto, Gherman Garcia Leal de Araújo, LANNA, D. P. D., Yamamoto, Sandra Mari, Duarte Lanna, Dante Pazzanese, SOUZA, L. L. de, Moraes, Salete Alves de, Dante Pazzanese Duarte Lanna, MORAES, S. A. de, Mário Adriano Ávila Queiroz, Duarte Lanna, Dante Pazzanese [UNESP]   +21 more
core   +1 more source

Transmissibilidade e efeito de Acremonium strictum em sementes de milho Transmissibility and effect of Acremonium strictum in maize seeds

Ciência e Agrotecnologia, 2003
Acremonium strictum é patogênico ao milho e a outras culturas, podendo causar podridão de sementes, podridão de colmos e a morte de plântulas. Trata-se de um fungo que pode interferir no vigor, estande e produtividade final das plantas.
Hudson Teixeira, José da Cruz Machado
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Novel Method for Managing Water and Electrolyte Balance after Transsphenoidal Surgery: Preliminary Study of Moderate Water Intake Restriction [PDF]

, 2014
2014-02Hyponatremia is a common and potentially serious complication of transsphenoidal surgery (TSS). Since September 2009, we have implemented moderate water intake restriction (
NAGATANI, TETSUYA, OKUMURA, ERIKO, WAKABAYASHI, TOSHIHIKO, TAKEUCHI, KAZUHITO   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of PF-05231023 during water restriction.

, 2018
Water intake (A), urine output (B), urine electrolyte concentrations (C) and urine electrolyte excretion (D) were measured in rats that were water restricted for 12 hours (n = 10). Water restriction was initiated immediately after dosing.
Xian Chen (107385), Matthew Zahner (5628785), Mylène Perreault (358280), Magalie Boucher (5628791), Alan Opsahl (5628788), Tod Turner (5628782), George DeMarco (1703356), Bryan Goodwin (653886)   +7 more
core   +1 more source