Results 101 to 110 of about 346,500 (295)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Behavior of Ships in Shallow and Restricted Waters [PDF]

Mathematical and Computational Applications, 2001
Ship motions in open waters and waves are always dynamic and most of the time are nonlinear. Even though behavior of ships in shallow and restricted waters does not sound as violent at first thought, it is equally important in terms of capsizing. There has been so many casualties reported that claimed so many lives.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bridging the Water Supply-Demand Gap in Australia: a Desalination Case Study

, 2013
Water supply in Australia mainly relies on precipitation and, therefore, is highly dependent on climate variability and change. Coupled with reduced rainfall reliability, population and economic growth and increasing competition for water resources ...
Stewart, Rodney, Sahin, Oz, Helfer, Fernanda   +2 more
core  

Effect of water restriction on feeding and metabolism in dairy cows

, 2001
We investigated how lactating cows are able to cope with a sustained water restriction. In experiment 1, body weight and meal patterns were recorded with ad libitum access to water (baseline) and during 8 days of 25 and 50% restriction of drinking water
Wolfgang Langhans, Markus Senn, Michael Kreuzer, Martine Steiger Burgos, Franz Sutter   +4 more
core   +1 more source

Changes in physiological parameters of boldo plants under water deficit conditions

Pesquisa Agropecuária Tropical
Water deficit is one of the main factors affecting the growth and development of boldo plants. This study aimed to evaluate the effects of water deficit on the growth and physiological parameters of Plectranthus barbatus.
Hellen Lilian Matos da Silva, José Holanda Campelo Júnior, Elisamara Caldeira do Nascimento, Francisco de Almeida Lobo, Jhonathann Willian Furquin da Silva, Niclene Ponce Rodrigues de Oliveira, Jholian Maicon Ribeiro-Santos   +6 more
doaj   +1 more source

Osmoregulatory and Antioxidants Modulation by Salicylic Acid and Methionine in Cowpea Plants under the Water Restriction. [PDF]

Plants (Basel), 2023
Oliveira APDS, Melo YL, de Alencar RS, Viégas PRA, Dias GF, Ferraz RLS, Sá FVDS, Dantas Neto J, Magalhães ID, Gheyi HR, de Lacerda CF, Melo AS.   +11 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Short water restriction episode in lactating Alpine and Saanen goats

, 2014
This project aims to assess the effect of a short episode of water restriction on high producing lactating goats. Water was withheld from eight Saanen and eight Alpine goats after the afternoon milking and until the following morning, on two consecutive ...
Giger-Reverdin, Sylvie, Duvaux-Ponter, Christine, Hamadeh, Shady K., JABER, Lina   +3 more
core   +1 more source

Mouse Water Restriction v1

This protocol describes a semi-customized workflow to perform water restriction with mice designated for future experiments. Water restriction is a common method used to increase engagement and motivation of mice performing behavioral experiments that use water as a reward.
Avalon Amaya, Jackie Swapp
openaire   +1 more source