Results 111 to 120 of about 346,500 (295)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Chronic water restriction reduces sensitivity to brain stimulation reward in male and female rats. [PDF]

Physiol Behav, 2023
Donka RM, Hsu T, Roitman MF, Roitman JD.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Effect of Water Restriction on Performance and Behaviour of Broiler Breeders [PDF]

, 1998
A study was carried out to investigate the effect of water restriction on various traits of broiler breeders under tropical conditions. The experimental treatment comprised of water available 24h/d and restricted to 8h/d and 6h/d.
Mohammed, Mustafa Fadil
core  

Chitosan mitigates water stress in cowpea plants through modulation of growth, homeostasis, and antioxidant activities

Frontiers in Plant Science
IntroductionClimate change and population growth increase food demand, especially in semi-arid regions. Water deficit affects cowpea productivity, but foliar application of chitosan can improve its tolerance, stimulating antioxidant activity and growth ...
Rayanne Silva de Alencar, Priscylla Marques de Oliveira Viana, Guilherme Felix Dias, Semako Ibrahim Bonou, Leticia Diniz Ribeiro, Yngrid Mikhaelly Lourenço de Araujo, Igor Eneas Cavalcante, Hermes Alves de Almeida, Pedro Roberto Almeida Viégas, Alberto Soares de Melo   +9 more
doaj   +1 more source

Citric Acid Water Restriction v1

, 2021
How to prepare and carry out citric acid water restriction for motivating mice to engage in behaviour.
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Illinois Community Water Supply Wells [PDF]

, 2006
Illinois Community Water Supply Wells - Illinois has abundant buried groundwater reserves that supply millions of gallons of groundwater per day for public, agricultural, and industrial/commercial use.
Illinois State Water Survey
core  

Sodium metabolism during acclimation to water restriction by wild mice, Mus musculus

, 1981
Changes in sodium and potassium balance and urinary aldosterone excretion (free plus “acid labile”) were surveyed in house mice acclimating initially to 1/2 the ad libitum water ration and later to 1/4 of ad libitum.
T. M. McKenna, H. Haines
core   +1 more source

Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Dog With Meningoencephalitis of Unknown Etiology

Veterinary Medicine and Science
A 5‐year‐old castrated male Maltese dog presented with generalized tonic‐clonic cluster seizures. The seizures first occurred 10 days prior and progressed gradually.
Yelim Lee, Jooyoung Park, Yeon Chae, Taesik Yun, Hakhyun Kim, Byeong‐Teck Kang   +5 more
doaj   +1 more source