Results 41 to 50 of about 469,584 (298)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
A precipitation recycling network to assess freshwater vulnerability : challenging the watershed convention [PDF]
, 2019 Water resources and water scarcity are usually regarded as local aspects for which a watershed-based management appears adequate. However, precipitation, as a main source of freshwater, may depend on moisture supplied through land evaporation from ...
Keune, Jessica, Miralles, Diego
core +3 more sources
Globalization of Freshwater Resources: Innovative Management Strategy
Foresight and STI Governance, 2010 The population of the world has grown substantially during the last half a century, and the demand for water amounted to one third of contemporary volume.The paper investigates the issue of water shortage which increases more rapidly than it was ...
Marina Boykova, Diana Krupnikova
doaj +1 more source
Salinity impacts on irrigation water-scarcity in food bowl regions of the US and Australia
Environmental Research Letters, 2022 Irrigation water use and crop production may be severely limited by both water shortages and increased salinity levels. However, impacts of crop-specific salinity limitations on irrigation water scarcity are largely unknown.
Josefin Thorslund +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Water scarcity assessment index from the realistic perspective of human basic water requirements
Environmental and Sustainability IndicatorsSignificant population growth with rapid economic development have led to water scarcity problems around the world. Currently, most of the simple water scarcity assessment methods only refer to per capita water use, failing to take into account actual ...
Rundong Liao
doaj +1 more source
Elementa: Science of the Anthropocene, 2016 We present an improved water-scarcity metric we call water depletion, calculated as the fraction of renewable water consumptively used for human activities. We employ new data from the WaterGAP3 integrated global water resources model to illustrate water
Kate A. Brauman +4 more
doaj +1 more source
Sensitivity of water scarcity events to ENSO-driven climate variability at the global scale [PDF]
Hydrology and Earth System Sciences, 2015 Globally, freshwater shortage is one of the most dangerous risks for society. Changing hydro-climatic and socioeconomic conditions have aggravated water scarcity over the past decades.
T. I. E. Veldkamp +4 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source