Results 121 to 130 of about 1,114,301 (300)

Report and Path Forward Texas Water Technology Roadmap Forum

, 2015
The forum report focuses on a pathway to help solve Texas’ water problems and speed water technology from lab, to market, to application. Specific strategies suggested to address problems include: •Development of a cyberinfrastructure for information ...
The Water Institute of Texas, STAR Park, The Meadows Center for Water and the Environment, AccelerateH2O, RCN-CE3SAR   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Best Management Practices and Standards, Training, and Tools to Increase Resilience of the Edwards Aquifer Water Supply During Emergency Fire Control

, 2023
In 2019 the Institute for Water Resources Science and Technology at Texas A&M University-San Antonio began work funded by the Proposition 1 Edwards Aquifer Protection Venue Project to develop Best Management Practices (BMPs) for protecting Edwards ...
Institute for Water Resources Science and Technology, Den, Walter   +1 more
core  

Fe-electrocatalytic deoxygenative Giese reaction

Nature Communications
A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported. Hydroxyl groups are among the most abundant functional groups, and thus, the development of efficient reactions for their conversion has significant importance in medicinal and
Longhui Yu, Shangzhao Li, Hiroshige Ogawa, Yilin Ma, Qing Chen, Ken Yamazaki, Yuuya Nagata, Hugh Nakamura   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Groundwater quality assessment using groundwater pollution index (PIG) and non-carcinogenic human health risk assessment of fluoride and nitrate (HHR) in a semi-arid region of Mascara (northwestern of Algeria)

Journal of Degraded and Mining Lands Management
This article discusses nitrate and fluoride contamination and potential health risks for men, women, and children in the Mascara region (northwestern Algeria). To achieve this objective, the Groundwater Pollution Index (PIG) was used to assess the health
Benyelkhlef Benamina, Abdelkader Bentabet, Habib Azzaz, Ali Dahmani, Abderrahmane Hamimed   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Safety analysis of a compact integral small light water reactor

, 2020
Thesis: S.M., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, May, 2020Cataloged from the official PDF of thesis.Includes bibliographical references (pages 110-112).Small modular reactors (SMRs) hold great promise in
Cheng, Zhiyuan,S.M.Massachusetts Institute of Technology.
core