Results 111 to 120 of about 1,114,301 (300)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The chemical reactions in electrosprays of water do not always correspond to those at the pristine air–water interface

, 2019
The recent application of electrosprays to characterize the air–water interface, along with the reports on dramatically accelerated chemical reactions in aqueous electrosprays, have sparked a broad interest.
Gallo Junior, Adair, Goddard, William A., Mishra, Himanshu, Nielsen, Robert J., Santana, Adriano, Farinha, Andreia S. F., Dinis Veloso Guerreiro, Miguel, Emwas, Abdul-Hamid M.   +7 more
core   +1 more source

Comprehensive objective function- guided decomposition-prediction co-optimization framework: Enhanced Transformer model for high-accuracy forecasting of non-stationary runoff

Journal of Hydrology: Regional Studies
Study region: In the Fen River Basin: Study focus: This study proposes a novel monthly runoff forecasting framework that integrates a Comprehensive Objective Function (COF) to guide the optimization of a hybrid model combining Sequential Variational Mode
Xiaoqi Guo, Xuehua Zhao, Xueping Zhu, Bowen Zhu, Qiucen Guo, Xixi Wu, Huifang Wang, Jiatong An   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature

Communications Biology
The placenta is a unique organ for ensuring normal embryonic growth in the uterine. Here, we found that maternal RNA transcription in Dlk1-Dio3 imprinted domain is essential for placentation.
Ximeijia Zhang, Hongjuan He, Haoran Yu, Xiangqi Teng, Ziwen Wang, Chenghao Li, Jiahang Li, Haopeng Yang, Jiwei Shen, Tong Wu, Fengwei Zhang, Yan Zhang, Qiong Wu   +12 more
doaj   +1 more source

Assessing the effects of combined future climate and land use/cover changes on streamflow in the Upper Fen River Basin, China

Journal of Hydrology: Regional Studies
Study region: Tributaries of the Yellow River, Upper Fen River Basin, China. Study focus: The current research analyzed the streamflow changes resulting from interactions between climate and land use/cover (LULC) under Shared Socioeconomic Pathways (SSPs)
Xixi Wu, Xuehua Zhao, Pan Chen, Bowen Zhu, Wenjun Cai, Wenyu Wu, Qiucen Guo, Marie Rose IRIBAGIZA   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Technology Transfer for Development: Insights from the Introduction of Low Cost Water Well Drilling Technology to Uganda [PDF]

, 2003
Third World development theory and practice are changing so rapidly that it is important to critically examine the fashions of today before they become history.
Danert, Kerstin
core  

The Effects of Different Improvement Measures on Soil Moisture Characteristics in Cold-Soaked Fields and on Maize Root Development and Growth

Agriculture
To clarify the effects of pond excavation and field elevation combined with biochar application on soil improvement and maize growth in cold-soaked fields in northern China, a two-year field experiment was conducted using maize as the test crop under ...
Chenyan Tang, Yuxuan Wang, Chengzhi Zhao, Haoqian Yang, Chengdong Jia, Lijian Zheng, Juanjuan Ma   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source