Results 91 to 100 of about 1,114,301 (300)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Modelling as intervention technology: Science, politics, and water conflicts
Water AlternativesIn water conflicts, models and their creators are often seen as guides that help public and policy actors make sense of controversies and formulate responses.
Ehsan Nabavi
doaj
Scientific ReportsThe effectiveness of air-entraining agents in enhancing the frost resistance of concrete is significantly reduced under low-pressure conditions, such as those found in plateau and alpine regions, leading to severe freeze–thaw damage.
Ling-Yun Feng +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 1992 82 pgs.The purpose of this report is to further communicate the Subcommittee's interagency coordination and information exchange efforts. The report (1) provides an overview of significant Federal research programs dealing with ground water, (2 ...
Subcommittee on Water Resources (Previously named the Subcommittee on Ground Water), Committee on Earth and Environmental Sciences, Federal Coordinating Council for Science, Engineering, and Technology (FCCSET)
core
, 2022 As a class of endocrine disrupting compounds (EDCs), corticosteroids (CSs) have attracted increasing attention due to their large excretion masses and toxic effects.
Zhang, Ai +7 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Role of Technological Science in Managing Water Related Issues
, 2022 COVID-19 has devastated the life of humans. It is nothing but the repercussion of devastation caused by humans on earth. We, the humans, have became so insensitive towards nature and its resources that we do not think twice before spoiling the flaura and fauna of it.
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source