Results 181 to 190 of about 710,433 (307)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Prediction of the water solubility by a graph convolutional-based neural network on a highly curated dataset. [PDF]

J Cheminform
Ulrich N, Voigt K, Kudria A, Böhme A, Ebert RU.   +4 more
europepmc   +1 more source

N-(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability. [PDF]

ChemMedChem, 2021
Ferlenghi F, Mari M, Gobbi G, Elisi GM, Mor M, Rivara S, Vacondio F, Bartolucci S, Bedini A, Fanini F, Spadoni G.   +10 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Optimising Cannabidiol Delivery: Improving Water Solubility and Permeability Through Phospholipid Complexation. [PDF]

Int J Mol Sci
Muta T, Khetan R, Song Y, Garg S.
europepmc   +1 more source

Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells. [PDF]

Int J Mol Sci, 2022
Pivarcsik T, Pósa V, Kovács H, May NV, Spengler G, Pósa SP, Tóth S, Nezafat Yazdi Z, Özvegy-Laczka C, Ugrai I, Szatmári I, Szakács G, Enyedy ÉA.   +12 more
europepmc   +1 more source

Water Soluble Bottlebrushes [PDF]

Polymer Journal, 1998
Seigou Kawaguchi, Katsumi Akaike, Zuo-Ming Zhang, Haruki Matsumoto, Koichi Ito   +4 more
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Structure-Dependent Water Solubility and Receptor Properties of C₃‑Symmetric Dendrimers Bearing Sumanene or Triphenylene Cores. [PDF]

ACS Org Inorg Au
Kulczyk S, Yakiyama Y, Koszytkowska-Stawińska M, Sakurai H, Kasprzak A.   +4 more
europepmc   +1 more source

Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability. [PDF]

RSC Med Chem, 2023
Maklakova SY, Lopukhov AV, Khudyakov AD, Kovalev SV, Mazhuga MP, Chepikova OE, Zamyatnin AA, Majouga AG, Klyachko NL, Beloglazkina EK.   +9 more
europepmc   +1 more source