Results 101 to 110 of about 304,910 (303)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The soil structural stability determined by the QuantiSlakeTest: Linkage with soil porosity, water-stable aggregate fractions and soil chemical properties

open access: yesGeoderma
Recently, the QuantiSlakeTest (QST) was developed which records mass loss or gain of intact soil samples during submergence, but it is yet unclear how slaking relates quantitatively to soil structure.
Toon van Dael   +2 more
doaj   +1 more source

Soil Organic-Matter in Water-Stable Aggregates Under Different Soil-Management Practices

open access: yesAgriculture, 2017
An experiment of different management practices in a commercial vineyard, which was established in 2006 in the locality of Nitra-Dražovce, Slovakia on Rendzic Leptosol, was used to evaluate the dynamics of soil organic-matter parameters during the years ...
Šimanský Vladimír   +4 more
doaj   +1 more source

Controlled Clustering of Superparamagnetic Nanoparticles using Block Copolymers : Design of New Contrast Agents for Magnetic Resonance Imaging

open access: yes, 2005
When polyelectrolyte-neutral block copolymers are mixed in aqueous solutions with oppositely charged species, stable complexes are found to form spontaneously. The mechanism is based on electrostatics, and on the compensation between the opposite charges.
Airiau, Marc   +6 more
core   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Influence of terrain attributes and soil properties on soil aggregate stability

open access: yesSoil and Water Research, 2011
The study on the relationship between the soil aggregates stability assessed using water stable aggregate (WSA) index and the selected terrain and soil properties was performed on a morphologically diverse study site in Chernozem soil region of Southern ...
Tereza ZÁDOROVÁ   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

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