Results 41 to 50 of about 8,623,109 (242)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Root exudate–assisted phytoremediation of copper and lead contamination using Rumex acetosa L. and Rumex K-1

Ecotoxicology and Environmental Safety
Heavy metal pollutants can be effectively removed from soil through phytoremediation using root exudates. Herein, experiments were conducted to assess the phytoremediation capabilities of Rumex acetosa L.
Mengfan He, Huizhen Yin, Zhuoliang Liu, Fan Luo, Xining Zhao, Huike Li, Xiaolin Song   +6 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Past, present and future of Indian sandalwood (Santalum album) cultivation and commercial prospects

Discover Applied Sciences
The sandalwood (Santalum album) tree holds significant commercial and cultural value globally, particularly in India. Among the 17 species within the Santalum genus, Santalum album stands out due to its high oil content and the presence of favorable ...
S. B. Chavan, A. R. Uthappa, A. R. Chichaghare, S. Suresh Ramanan, Raj Kumar, A. Keerthika, A. Arunachalam, Ramakrishna Hegde, Dinesh Jinger, Vijay Singh Meena, Manish Kumar, C. B. Harisha, V. D. Kakade, A. S. Morade, G. B. Rawale, Rupali Singh, K. Sammi Reddy   +16 more
doaj   +1 more source

When the taps run dry: Water stress and social unrest revisited

Revista UNISCI, 2018
Water stress presents a wide range of concerns that can jeopardize international security. Neo-Malthusians scholars constantly warn of water conflicts, while institutionalists argue that possible water conflicts are the result of poor water distribution ...
Alfonso Sánchez, Guillermo Rylance
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Early hyperspectral diagnosis of canopy water content for productivity-risk and water-management screening in rainfed winter oilseed rape

Agricultural Water Management
Rainfed winter oilseed rape is vulnerable to temporal mismatches between precipitation and crop water demand, creating a need for early indicators of water-related productivity risk. This study developed a hyperspectral framework to estimate canopy water-
Ming Jin, Xiaolin Song, Yang Liu, Bohui Ma, Jiyan Wang, Aini Hao, Zhiying Liu, Zijun Tang, Youzhen Xiang, Fucang Zhang   +9 more
doaj   +1 more source