Results 61 to 70 of about 8,623,109 (242)

Water in the 2010 Virginia General Assembly

open access: yes, 2010
The 2010 Virginia General Assembly convened January 13 and adjourned March 13. The reconvened (“veto”) session was held April 21. During the session, the Assembly considered 2964 measures, passing 1598 of them, defeating 1093, and continuing 273 until ...
Virginia Water Resources Research Center
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Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Water in the 2006 Virginia General Assembly

open access: yes, 2006
The 2006 Virginia General Assembly convened January 11 and adjourned March 11, with a reconvened (“veto”) session on April 19. The legislature considered 3287 measures; among the most important business was development of the biennial state budget. Below
Virginia Water Resources Research Center
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Water stress during flowering of cotton

open access: yesCalifornia Agriculture, 1970
A severe plant water deficit imposed for nine days during the peak flowering period of cotton reduced yield more than stress periods of comparable length imposed either early or late in the flowering period.
D Grimes, R Miller, L Dickens
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Water-Related Bills in the 2008 Virginia General Assembly

open access: yes, 2008
The 2008 Virginia General Assembly session opened January 9 and adjourned March 13. Work on the biennial state budget required a few additional days beyond the scheduled adjournment date of March 8.
Virginia Water Resources Research Center
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Effects of water stress on berry quality and organic acid synthesis gene expression in Beihong grape [PDF]

open access: yesGuoshu xuebao
[Objective] Water stress refers to the phenomenon in that the normal physiological function of plants is disrupted due to inadequate or excessive soil water. This condition is mainly categorized as waterlogging stress and drought stress.
WANG Jiayue   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Water in the 2001 General Assembly

open access: yes, 2001
The 2001 Virginia General Assembly lasted from January 10 to February 24. The House of Delegates and Senate considered 2645 bills and resolutions. By our reckoning, 123 of these had something to do with water resources or water-related activities.
Virginia Water Resources Research Center
core  

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