Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Evidence of Deep Water Penetration in Silica during Stress Corrosion Fracture [PDF]
, 2011 We measure the thickness of the heavy water layer trapped under the stress corrosion fracture surface of silica using neutron reflectivity experiments.
Bouchaud, E. +5 more
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Identification of Sunflower (Helianthus annuus L.) Genotypes Tolerant to Water Stres
Journal of Agricultural Sciences, 2018 The present research was carried out to determine water-stress tolerance of linoleic sunflower genotypes (P64LE119, PR63F73, P64LL62) grown under different water stress conditions [no water-stress (I100); mild water-stress (I70); strong water-stress (I35)
Ali Beyhan Uçak
doaj +1 more source
Better Performance of the Modified CERES-Wheat Model in Simulating Evapotranspiration and Wheat Growth under Water Stress Conditions [PDF]
, 2022 Yingnan Wei +6 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On the capillary stress tensor in wet granular materials
, 2011 This paper presents a micromechanical study of unsaturated granular media in the pendular regime, based upon numerical experiments using the discrete element method, compared to a microstructural elastoplastic model.
Alonso +33 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Identification of the water stress level in olive trees during pit hardening using the trunk growth rate indicator. [PDF]
, 2018 Water scarcity is generating an increasing interest in deficit irrigation scheduling. The trunk diameter fluctuations are daily cycles that have been suggested as tools for irrigation scheduling.
Andreu Cáceres, Luis +9 more
core
FTIR and XPS studies on corrosion resistant SiO2 coatings as a function of the humidity during deposition [PDF]
, 1996 The degradation of SiO2 coatings deposited on alloys by metal organic chemical vapour deposition (MOCVD) in sulphidizing high-temperature environments is determined by delamination and crack formation.
Fransen, T. +4 more
core +2 more sources