Results 81 to 90 of about 2,586,747 (309)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Evaluation of a net launcher for capturing urban gulls
Wildlife Society Bulletin, 2014 The capture of birds is a common part of many avian studies but often requires large investments of time and resources. We developed a novel technique for capturing gulls during the non‐breeding season using a net launcher that was effective and ...
Daniel E. Clark +4 more
doaj +1 more source
Investigating the Effect of Water Contamination on Gearbox Lubrication based on Motor Control Data from a Sensorless Drive [PDF]
, 2014 Water is one of the most significant destructive contaminations to lubricants which in turn lead to more power consumption and early damage to rotating machines.
Abusaad, Samieh +4 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Infrastructure water supply in Bauru: historical reflections [PDF]
, 2015 s aceptados sin presentacion / Accepted abstracts without ...
Ghirardello, Nilson +1 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Determinants of the influence of community participation on the sustainability of local system community-based sanitation programs in Temanggung Regency [PDF]
E3S Web of ConferencesCommunity-based Sanitation (SANIMAS) is an activity to address sanitation problems in Indonesia. 88% of communities in Temanggung Regency dispose of domestic wastewater directly into the river without any prior treatment.
Sunaryo Laillia Rakhmawati +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source