Results 81 to 90 of about 2,632,519 (299)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The physiological response of Populus tremula x alba leaves to the down-regulation of PIP1 aquaporin gene expression under no water stress. [PDF]
, 2013 In order to study the role of PIP1 aquaporins in leaf water and CO2 transport, several lines of PIP1-deficient transgenic Populus tremula x alba were generated using a reverse genetic approach. These transgenic lines displayed no visible developmental or
Secchi, Francesca, Zwieniecki, Maciej A
core +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
FishesFlow velocity is a critical factor in determining the suitability of fish habitats. Understanding the preference patterns of the four major Chinese carps (FMCCs) for different flow velocities is crucial for their habitat conservation and restoration.
Ning Qiu +5 more
doaj +1 more source
VEINS: Inverted Echo Sounders in the Denmark Strait, as part of, FS "Poseidon" Cruise 222/1, August 5, 1996 - August 12, 1996 [PDF]
, 1999 The overflow of cold dense water from the Denmark Strait is one of the key elements of the North Atlantic thermohaline circulation and has important consequences for global climate change.
Hargreaves, G. W.
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Reliable fault-tolerant model predictive control of drinking water transport networks [PDF]
, 2016 This paper proposes a reliable fault-tolerant model predictive control applied to drinking water transport networks. After a fault has occurred, the predictive controller should be redesigned to cope with the fault effect.
Garza Castañón, Luís Eduardo +3 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Zeolite-filled silicone rubber membranes. Experimental determination of concentration profiles [PDF]
, 1994 Permeant concentrations in silicalite-filled silicone rubber membranes during pervaporation of propanol/water mixtures were measured using multi-layered membranes.
Bargeman, D. +6 more
core +2 more sources