Results 91 to 100 of about 5,207,518 (299)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Seed Germination in Ginkgo biloba L. I. Influences of Cold Treatment, Gibberellic Acid and Red Light [PDF]
, 1974 The influences of cold treatment, gibberellic acid and red light treatment on rate of germination of seeds of Ginkgo biloba L. were followed for a 12-wk period. Dispersal units were collected, and the outer fleshy layer was removed soon after harvest. Of
Johnson, Michael I., Wickliff, James L.
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An Evaluation of the Effect of Discharging a High Quality Effluent into a Small Ozark Mountain Stream [PDF]
, 1990 Recently the newly constructed Fayetteville wastewater treatment plant went on line and directed a portion of its discharge to a point in the Mud Creek drainage basin that had previously not received any effluent.
Cotter, Floyd E. +2 more
core +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Urban Water Conservation and Efficiency Potential in California [PDF]
, 2014 Improving urban water-use efficiency is a key solution to California's short-term and longterm water challenges: from drought to unsustainable groundwater use to growing tensions over limited supplies.
Heather Cooley +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Sludge Production and Disposal for Small Cold Climate Bio-Treatment Plants [PDF]
, 1972 Ultimate disposal of wastewater sludge has long been a problem which to a large degree has been ignored. Haney (1971) stated that: "Until process sludge can be handled with minimum environmental impact, we cannot claim to have a viable wastewater ...
Tilsworth, Timothy
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