Results 111 to 120 of about 14,286,481 (305)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Water-Related Bills in the 2008 Virginia General Assembly

, 2008
The 2008 Virginia General Assembly session opened January 9 and adjourned March 13. Work on the biennial state budget required a few additional days beyond the scheduled adjournment date of March 8.
Virginia Water Resources Research Center
core  

Cost-Optimal Flexibilization of Drinking Water Pumping and Treatment Plants

, 2018
This paper examines potential cost savings attained through the flexible operation of water treatment plants and drinking water pumping and the benefits gained by investing in extended water storage capacities that enhance flexibility.
Hedda Gardian, Britta Zimmermann, Kurt Rohrig, Gardian, H., Zimmermann, Britta, Rohrig, Kurt   +5 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Physical and Chemical Water Quality of Ilam Water Treatment Plant [PDF]

Water usually has some dissolved elements such as solids and gasses. Existences of some elements in water are necessary for human health, but deficiency of many them can cause problems.
تردست, علی, عمارلوئی, علی, مظلومی, سجاد, نوروزی, مهدی, کرمی تبار, یزدان, فضل زاده دویل, مهدی, دهقانی, محمدهادی   +6 more
core  

Advancements and challenges of micro/nanobubble technology for sustainable agriculture: A systematic and bibliometric review

Agricultural Water Management
Micro- and nanobubbles (MNBs) have gained increasing scientific interest due to their unique physicochemical properties and promising applications in agriculture and water management.
A. Balea, G. Nieto, F. Hadinejad, E. Fuente, J.L. Sanchez-Salvador, M.C. Monte, C. Negro, A. Blanco   +7 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Self-regulation of Lewis acid sites on FeOCl toward piezo-self-Fenton reaction for continuous hydroxyl radicals generation

Nature Communications
Clarifying the structure-property relationship is critical to the design of high-performance piezocatalysts. Herein, with iron oxychloride (FeOCl) as the model piezocatalyst, a systematic investigation into the evolution of surface properties by the ...
Haojie Dong, Yuanyi Zhou, Zhi Li, Wei Liu, Shaobin Li, Mingshan Zhu   +5 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source