Results 61 to 70 of about 104,858 (213)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Mechanisms of microbial and functional gene influences on nitrogen cycle in pumping station forebays
Water Science and EngineeringNitrogen pollution in rivers has long been a key environmental factor hindering ecosystem recovery. As critical nodes in water systems, pumping station projects further complicate river environmental issues.
Wei-wei Song +5 more
doaj +1 more source
Efficiency of an Integrated Purification System for Pig Slurry Treatment under Mediterranean Climate
Agronomy, 2020 The intensification of pig production is considered a risky activity for the environment when the generated pig slurry is not adequately treated. In addition, intensive agriculture practices where pig slurry is applied to the cropland could cause nitrate
Martire Angélica Terrero +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The Innovative Activity of Enterprises in the Context of Providing Information Security
Problemi Ekonomiki, 2015 The aim of the article is to study the peculiarities of the innovative activity in the context of providing the enterprise information security. By analyzing, systematizing and summarizing the scientific works of many scientists the essence of the ...
Sazonets Olga M. , Sipaylo Leonid G.
doaj
Rice, 2018 Background Monodehydroascorbate reductase (MDAR or MDHAR), which is responsible for growth, development and stress response in plants, is a key enzyme in the maintenance of the ascorbate acid (AsA) pool through the AsA–glutathione (AsA–GSH) cycle.
Jianping Liu +8 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
AgronomyRecently, the crop forcing technique (summer pruning that “forces” the vine to start a new cycle) has proven to be effective in delaying the harvest date and increasing must acidity, but also reducing the yield.
Jordi Oliver-Manera +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source