Results 81 to 90 of about 2,839,271 (263)

Performance of AquaCrop and DSSAT Models for Greenhouse Grown Tomato Under High-Temperature Conditions

Horticulturae
High temperature is a primary meteorological hazard restricting crop yield and quality, particularly in semi-automatic greenhouses. However, the accuracy of crop models under controlled high-temperature conditions in greenhouses has rarely been examined.
Xuewen Gong, Wei Zeng, Tianli Ren, Xiaoming Li, Yanbin Li, Jiankun Ge, Chitao Sun, Huanhuan Li   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Design and Implementation of Low-Cost Redundant Subsystems for PFAL Reliability

Agriculture
The increasing adoption of Plant Factories with Artificial Lighting (PFAL) has intensified the reliance on Internet of Things (IoT) technologies for real-time monitoring and control of environmental and operational variables.
Gracia Muñoz Jaimes, Mauricio Samano Solano, Luis Arturo Soriano   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Optimizing water and nitrogen management to reduce basal nitrogen inputs, improve nitrogen uptake and utilization efficiencies, and achieve high yields and low soil nitrate residue in wheat production

Crop and Environment
Excessive basal nitrogen (N) inputs and improper water management limit both wheat yields and N use efficiency. Thus, a field experiment was conducted for two years to evaluate whether optimizing water and N management could reduce basal N inputs ...
Wen Li, Yuyan Fan, Qiu Yang, Wen Lin, Jianfu Xue, Yuechao Wang, Zhiqiang Gao   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Ecological risk from wastewater irrigation: a comprehensive assessment of heavy metal contamination in Egyptian soils

Bulletin of the National Research Centre
Background Continuous irrigation with poor-quality water poses a major threat to soil health and food security through the progressive buildup of potentially toxic elements (PTEs). This study conducted a detailed ecological risk assessment of nickel (Ni),
Monier M. Wahba, Alaa Zaghloul
doaj   +1 more source

Almond yield prediction at orchard scale using satellite-derived biophysical traits and crop evapotranspiration combined with machine learning

Frontiers in Agronomy
Accurate almond yield prediction is essential for supporting decision-making across multiple scales, from individual growers to international markets.
Manuel Quintanilla-Albornoz, Manuel Quintanilla-Albornoz, Xavier Miarnau, Magi Pamies-Sans, Joaquim Bellvert   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source