Results 81 to 90 of about 104,858 (213)

Monitoring long-term peat subsidence with subsidence platens in Zegveld, The Netherlands

Geoderma
Peat oxidation in peat meadow areas is causing greenhouse gas emissions as well as land subsidence. Due to yearly fluctuations in soil surface level, long-term monitoring is needed to determine long-term net subsidence rates.
Harry T.L. Massop, Rudi Hessel, Jan J.H. van den Akker, Sanneke van Asselen, Gilles Erkens, Paul A. Gerritsen, Frank H.G.A. Gerritsen   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Design and Implementation of Low-Cost Redundant Subsystems for PFAL Reliability

Agriculture
The increasing adoption of Plant Factories with Artificial Lighting (PFAL) has intensified the reliance on Internet of Things (IoT) technologies for real-time monitoring and control of environmental and operational variables.
Gracia Muñoz Jaimes, Mauricio Samano Solano, Luis Arturo Soriano   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Optimizing water and nitrogen management to reduce basal nitrogen inputs, improve nitrogen uptake and utilization efficiencies, and achieve high yields and low soil nitrate residue in wheat production

Crop and Environment
Excessive basal nitrogen (N) inputs and improper water management limit both wheat yields and N use efficiency. Thus, a field experiment was conducted for two years to evaluate whether optimizing water and N management could reduce basal N inputs ...
Wen Li, Yuyan Fan, Qiu Yang, Wen Lin, Jianfu Xue, Yuechao Wang, Zhiqiang Gao   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ecological risk from wastewater irrigation: a comprehensive assessment of heavy metal contamination in Egyptian soils

Bulletin of the National Research Centre
Background Continuous irrigation with poor-quality water poses a major threat to soil health and food security through the progressive buildup of potentially toxic elements (PTEs). This study conducted a detailed ecological risk assessment of nickel (Ni),
Monier M. Wahba, Alaa Zaghloul
doaj   +1 more source

Almond yield prediction at orchard scale using satellite-derived biophysical traits and crop evapotranspiration combined with machine learning

Frontiers in Agronomy
Accurate almond yield prediction is essential for supporting decision-making across multiple scales, from individual growers to international markets.
Manuel Quintanilla-Albornoz, Manuel Quintanilla-Albornoz, Xavier Miarnau, Magi Pamies-Sans, Joaquim Bellvert   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source