Results 91 to 100 of about 2,659,137 (363)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Evapotranspiration and water use efficiency in relation to climate and canopy nitrogen in U.S. forests [PDF]

, 2016
Understanding relations among forest carbon (C) uptake and water use is critical for predicting forest-climate interactions. Although the basic properties of tree-water relations have long been known, our understanding of broader-scale patterns is ...
Anav, Atkin, Badeck, Baldocchi, Baldocchi, Baldocchi, Baldocchi, Baldocchi, Barbour, Barbour, Barbour, Barnard, Beer, Belmecheri, Berry, Betts, Bolster, Bonan, Bonan, Bright, Brugnoli, Buckley, Canadell, Carnicer, Catovsky, Cernusak, Chen, Clark, Craig, Davin, Desai, Dickinson, Dongmann, Donovan, Dore, Evans, Ewers, Farquhar, Farquhar, Farquhar, Farquhar, Farquhar, Federer, Fernández-Martínez, Fernández-Martínez, Flanagan, Flexas, Gessler, Gessler, Grams, Grassi, Guerrieri, Heimann, Jennings, Keenan, Keitel, Kergoat, Kunert, Law, Lee, Leonelli, Lepine, Liang, Loescher, Luyssaert, Lévesque, Magnani, Martin, Martínez-Vilalta, Meinzer, Meir, Michelot, Moffat, Monson, Moreno-Gutiérrez, Niinemets, Niu, Ollinger, Ollinger, Pan, Pan, Papale, Paquette, Ponton, Post, Potter, Powell, Reichstein, Reichstein, Renninger, Richardson, Ripullone, Roden, Roden, Roden, Roman, Sage, Scartazza, Scheidegger, Schulze, Seibt, Siegwolf, Smith, Smith, Song, Sullivan, Tang, Tang, Tardieu, Valentini, Valentini, Wang, Warren, Wehr, Wright, Xiao, Xiao, Xu, Zhang, Zhu   +119 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Inter-sectoral Water Use in South Africa: Efficiency Versus Equity [PDF]

While water supply sources are dwindling in South Africa, the demand for the scarce water resource is increasing. This situation requires a switch from supply to demand management of water in the country.
Juana, James S., Kirsten, Johann F., Strzepek, Kenneth M.   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Drone-Based Hyperspectral and Thermal Imagery for Quantifying Upland Rice Growth and Water Use Efficiency After Biochar Application

, 2021
Hongxiao Jin, Christian Josef Köppl, Benjamin Fischer, Johanna Rojas Conejo, Mark S. Johnson, Laura Morillas, Steve W. Lyon, Ana María Durán‐Quesada, Andrea Suárez Serrano, Stefano Manzoni, Mónica García   +10 more
openalex   +2 more sources

Water use efficiency of tomatoes - in greenhouses and hydroponics [PDF]

Massive amounts of water are required for the production of our food, varying from several cubic metres per kilogram of beef to as low as 4 litres per kilogram for tomatoes grown in high-tech glasshouses.
Nederhoff, E.M., Stanghellini, C.
core   +1 more source

Effect of Flow Steering Angle Toward the Hydrokinetic Turbine Performance [PDF]

, 2019
The kinetic turbine is one of the solutions for use in low-speed river flows ranging from 0.01–2.8 m/s. This kinetic turbine is used as a conversion equipment to convert the water kinetic energy into an electrical energy.
Soenoko, R. (Rudy), Wijaya, H. (Hastono)
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Development trajectories of river basins: a conceptual framework [PDF]

River basin development / Water use / Water demand / Water supply / Water scarcity / Water allocation / Water conservation / Farm ponds / Tanks / Reservoirs / Irrigation management / Water use efficiency / Aquifers ...
Molle, F.
core