Results 61 to 70 of about 492,459 (298)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Very compact millimeter sizes for composite star-forming/AGN submillimeter galaxies [PDF]

, 2017
We report the study of far-IR sizes of submillimeter galaxies (SMGs) in relation to their dust-obscured star formation rate (SFR) and active galactic nuclei (AGN) presence, determined using mid-IR photometry. We determined the millimeter-wave ($\lambda_{\
Aretxaga, Itziar, Bisigello, Laura, Caputi, Karina, Dunlop, James S., Hatsukade, Bunyo, Hughes, David H., Ikarashi, Soh, Iono, Daisuke, Ivison, R. J., Izumi, Takuma, Kashikawa, Nobunari, Kawabe, Ryohei, Kohno, Kotaro, Koyama, Yusei, Lagos, Claudia D. P., Motohara, Kentaro, Nakanishi, Kouichiro, Ohta, Kouji, Tamura, Yoichi, Umehata, Hideki, Wilson, Grant W., Yabe, Kiyoto, Yun, Min S.   +22 more
core   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Empowering nanophotonic applications via artificial intelligence: pathways, progress, and prospects

Nanophotonics
Empowering nanophotonic devices via artificial intelligence (AI) has revolutionized both scientific research methodologies and engineering practices, addressing critical challenges in the design and optimization of complex systems.
Chen Wei, Yang Shuya, Yan Yiming, Gao Yuan, Zhu Jinfeng, Dong Zhaogang   +5 more
doaj   +1 more source

Gravitational waves from neutron stars

, 1996
Contents: 1. Introduction 2. Spontaneous symmetry breaking 2.1 Review of classical results about Maclaurin/Jacobi ellipsoids 2.2 Spontaneous breaking of symmetry: a general phenomenom 2.3 Previous results for compressible Newtonian stars 2.4 Generation of gravitational waves 2.5 Finding the equilibrium configurations of a rotating star in the Newtonian
Bonazzola, S., Gourgoulhon, E.
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Physics-informed Priors Improve Gravitational-wave Constraints on Neutron-star Matter

The Astrophysical Journal Letters
Gravitational-wave astronomy shows great promise in determining nuclear physics in a regime not accessible to terrestrial experiments. We introduce physics-informed priors constrained by nuclear theory and perturbative quantum chromodynamics calculations,
Spencer J. Magnall, Christian Ecker, Luciano Rezzolla, Paul D. Lasky, Simon R. Goode   +4 more
doaj   +1 more source

Inferring the post-merger gravitational wave emission from binary neutron star coalescences [PDF]

, 2017
We present a robust method to characterize the gravitational wave emission from the remnant of a neutron star coalescence. Our approach makes only minimal assumptions about the morphology of the signal and provides a full posterior probability ...
Bauswein, Andreas, Chatziioannou, Katerina, Clark, James Alexander, Cornish, Neil, Littenberg, Tyson B., Millhouse, Margaret   +5 more
core   +2 more sources

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

CIRCUSTELLAR MATTER ACTIVITY IN AE/BE HERBIG STAR MWC 614

Odessa Astronomical Publications, 2017
The results of spectral observations of the Herbig  Ae/Be  type  star  HD  179218  are  presented.  Two wave-like  cycles  of  variability  in  the  parameters  of hydrogen lines Hα and Hβ with a characteristic time of ~ 40 days are revealed.
N. Z. Ismailov, A. N. Adigezalzade, U. Z. Bashirova   +2 more
doaj   +1 more source