Results 191 to 200 of about 2,844,522 (254)

Comparative multimodal calibration of patient‐specific atrial fibrillation models: Impact of imaging and electrophysiology data on arrhythmogenic substrate identification

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Comparative multimodal calibration of patient‐specific left atrial (LA) models to identify arrhythmogenic substrates in atrial fibrillation (AF). A, LA models shown in posterior and anterior views, calibrated separately using: late gadolinium enhancement magnetic resonance imaging (LGE‐MRI) image intensity ratio (IIR; blue–red ...
Mahmoud Ehnesh   +14 more
wiley   +1 more source

Acute mechanical stretch enhances β‐adrenergic–protein kinase A signalling and increases susceptibility to ventricular arrhythmias

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Mechanical stretch alters Cav3‐associated membrane organisation and enhances β‐adrenergic receptor (βAR)–protein kinase A (PKA)‐dependent Ca2+ instability. Schematic overview of the experimental strategy and proposed mechanism: rat hearts were studied by Langendorff optical mapping using a fluid‐filled left ventricular (LV ...
Houcheng Wang   +7 more
wiley   +1 more source

Channelrhodopsin ion selectivity determines mechanisms and efficacy of optogenetic defibrillation in human atria and ventricles

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A, we used in silico models of human cardiomyocytes and microelectrode recordings on transgenic zebrafish hearts to study electrophysiology during optogenetic perturbations. Specifically, we compared effects of three distinct classes of channelrhodopsins: the cation non‐selective Chlamydomonas reinhardtii channelrhodopsin‐2 (ChR2)
Sophia Ohnemus   +12 more
wiley   +1 more source

Design Principles for Light‐Scattering Reservoir Computing at the Edge of Chaos

open access: yesAdvanced Computing, Volume 1, Issue 1, December 2026.
Here we realize a light‐scattering reservoir computer operating with measurement‐modulation feedback, physically tunable in three axes—reservoir dynamics, input‐reservoir coupling, and reservoir interconnectivity. Sweeping each axis, we locate the axis‐specific optimum of memory capacity; the dynamic axis displays the sharpest optimum.
Geon Kim, YongKeun Park
wiley   +1 more source

An Intensity Measure‐Based Methodology for Ground Motion Orientation in Seismic Structural Assessment

open access: yesEarthquake Engineering &Structural Dynamics, Volume 55, Issue 15, Page 3859-3879, December 2026.
ABSTRACT In current dynamic time history assessment protocols, ground motion recordings are mostly oriented along fixed sensor directions. Consequently, the orientation of the principal resultant of rupture energy, which may control the maximum structural demand, remains undefined, precluding consistent correlation with physically detrimental ...
Santiago Londono‐Lopez   +4 more
wiley   +1 more source

A Variational Physics‐Informed Neural Network Framework for Simulating Nonlinear Elastic Wave Propagation

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.
ABSTRACT This work employs Variational Physics‐Informed Neural Networks (VPINNs) to solve the forward problem of one‐dimensional wave propagation in nonlinear elastic solids. A first‐order elastodynamic formulation is adopted, where particle velocity and strain serve as the primary field variables.
Benjamin Ankay, Okyay Altay
wiley   +1 more source

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