Results 51 to 60 of about 375,529 (293)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Structure and realization of pole-shared switched-current complex wavelet filter [PDF]

, 2015
A pole-shared switched-current complex wavelet filter structure with follow-the-leader feedback configuration is proposed for synthesizing the real and imaginary approximation functions with the same poles.
He, Yigang, Sun, Yichuang, Zhao, Wenshan
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sub-second dynamics of theta-gamma coupling in hippocampal CA1

eLife, 2019
Oscillatory brain activity reflects different internal brain states including neurons’ excitatory state and synchrony among neurons. However, characterizing these states is complicated by the fact that different oscillations are often coupled, such as ...
Lu Zhang, John Lee, Christopher Rozell, Annabelle C Singer   +3 more
doaj   +1 more source

Error bounds of a function related to generalized Lipschitz class via the pseudo-Chebyshev wavelet and its applications in the approximation of functions

Karpatsʹkì Matematičnì Publìkacìï, 2022
In this paper, a new computation method derived to solve the problems of approximation theory. This method is based upon pseudo-Chebyshev wavelet approximations. The pseudo-Chebyshev wavelet is being presented for the first time.
S. Lal, S. Kumar, S.K. Mishra, A.K. Awasthi   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Assessing the Speciation of Lutjanus campechanus and Lutjanus purpureus through Otolith Shape and Genetic Analyses

Fishes, 2022
Based on their morphological and genetic similarity, several studies have proposed that Lutjanus campechanus and Lutjanus purpureus are the same species, but there is no confirmed consensus yet.
Angel Marval-Rodríguez, Ximena Renán, Gabriela Galindo-Cortes, Saraí Acuña-Ramírez, María de Lourdes Jiménez-Badillo, Hectorina Rodulfo, Jorge L. Montero-Muñoz, Thierry Brulé, Marcos De Donato   +8 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

An Efficient Technique for Classification of Electrocardiogram Signals

Advances in Electrical and Computer Engineering, 2009
This work describes a Radial Basis Function (RBF) neural network method used to analyze ECG signals for diagnosing cardiac arrhythmias effectively. The proposed method can accurately classify and differentiate normal (Normal) and abnormal heartbeats ...
EBRAHIMZADEH, A., KHAZAEE, A.
doaj   +1 more source