Results 81 to 90 of about 476,480 (304)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

APLICACIÓN DE UN TRATAMIENTO QUÍMICO PARA EL CONTROL DE PARAFINAS EN LA TUBERÍA DE PRODUCCIÓN EN EL CRUDO DEL CAMPO ESCUELA COLORADO

Revista Fuentes El Reventón Energético, 2019
This paper presents the implementation of a chemical treatment in a pilot well of the Colorado Field to prevent the precipitation and deposition of paraffins in the production tubing.
Crisóstomo Barajas Ferreira, Emiliano Ariza León, Miguel Amaya Bohorquez, Rosa Ines Pedreros Martínez   +3 more
doaj  

Comparison of the leaf epidermal micromorphology between female and male Idesia polycarpa Maxim.

Xibei zhiwu xuebao
[Objective] The study aims to explore the micromorphological characteristics of leaf epidermis of Idesia polycarpa Maxim. and investigate differences between the female and male plants in order to provide references for the mining and utilization of ...
YIN Dandan, SU Shang
doaj   +1 more source

Chemical Composition and Crystal Morphology of Epicuticular Wax in Mature Fruits of 35 Pear (Pyrus spp.) Cultivars

Frontiers in Plant Science, 2018
An evaluation of fruit wax components will provide us with valuable information for pear breeding and enhancing fruit quality. Here, we dissected the epicuticular wax concentration, composition and structure of mature fruits from 35 pear cultivars ...
Xiao Wu, Hao Yin, Zebin Shi, Yangyang Chen, Kaijie Qi, Xin Qiao, Guoming Wang, Peng Cao, Shaoling Zhang   +8 more
doaj   +1 more source

Plant water resource partitioning and isotopic fractionation during transpiration in a seasonally dry tropical climate [PDF]

, 2017
Lake Chala (3 degrees 19' S, 37 degrees 42' E) is a steep-sided crater lake situated in equatorial East Africa, a tropical semiarid area with a bimodal rainfall pattern. Plants in this region are exposed to a prolonged dry season, and we investigated if (
Bodé, Samuel, Boeckx, Pascal, De Wispelaere, Lien, Hemp, Andreas, Hervé Fernández, Pedro Alejandro, Verschuren, Dirk   +5 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Simple SERS-Based Trace Sensing Platform Enabled by AuNPs-Analyte/AuNPs Double-Decker Structure on Wax-Coated Hydrophobic Surface

Frontiers in Chemistry, 2018
In this work, a simple and versatile SERS sensing platform enabled by AuNPs-analyte/AuNPs double-decker structure on wax-coated hydrophobic surface was developed using a portable Raman spectrometer.
Huixiang Wu, Huixiang Wu, Yi Luo, Yikun Huang, Qiuchen Dong, Changjun Hou, Danqun Huo, Jing Zhao, Yu Lei, Yu Lei   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research of binders wetting property for preparation of feedstocks [PDF]

, 1998
The article describes the research of binders wetting property for preparation of feedstocks. The compositions of binders such as: 15% of polypropylene+85% of paraffin wax, 35% of polypropylene+65% of paraffin wax and 65% of polypropylene+35% of paraffin
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core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source