Results 61 to 70 of about 28,362 (249)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Application of wax therapy method in pipe difficult in PICC patients

Huli yanjiu, 2015
AbstractObjective:To probe into the effect of wax therapy for the treatment of pipe difficult in PICC patients.Methods:A total of 560 cases of patients received the first chemotherapy and PICC were selected in our hospital from 2013 August to 2014 ...
梁熙德, 刘冬梅, 林妙芬, 朱琳
doaj  

THE COMPARATIVE EFFECTS OF VRUDDHADARVADI UPANAHA AND WAX THERAPY IN THE PAIN MANAGEMENT OF JANU SANDHIGATAVATA W.S.R. TO OSTEOARTHRITIS OF KNEE JOINT

AYUSHDHARA, 2020
A clinical trial was conducted to evaluate the efficacy of different treatment modalities in Janu Sandhigatavata. The Lakshanas of Janu Sandhigatavata as per classics are Shotha, Shoola, Prasaranaa kunchanayovedana, and Atopa are like the symptoms of Osteoarthritis of knee joint i.e., pain, swelling, crepitation and joint restriction.
null Snigdha Rani Patra, null Manjunath Akki, null G G Patil   +2 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Successful Treatment of an Angiosarcoma of the Nose with Radiation Therapy

Case Reports in Oncology, 2012
Angiosarcoma is a rare, aggressive malignancy of endothelial cells lining blood vessels. It poses therapeutic challenges since there is no standard established treatment.
Vatsal B. Patel, Tod W. Speer
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

776 Use of Paraffin Wax During Occupational Therapy Treatment of Burn Survivors

Journal of Burn Care & Research
Abstract Introduction Burn survivors face long and often painful rehabilitation after injury. Unfortunately, the severe pain from burn injuries can lead to chronic pain and stress-related disorders.
openaire   +1 more source

Mechanisms and Evidence-Based Advantages of Traditional Chinese Medicine Wax Therapy in Chronic Disease Treatment

Journal of Contemporary Medical Practice
Objective: To systematically elaborate the core mechanisms of Traditional Chinese Medicine (TCM) wax therapy in treating chronic diseases and provide evidence-based support for its standardized clinical application. Methods: Databases including CNKI, PubMed, and Web of Science (2010-2024) were searched to include clinical studies, basic experiments ...
Jian Song, Jing Yuan, Kaiqiang Meng
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

An Investigation into the Relationship between Xanthan Gum Film Coating Materials and Predicted Oro-Esophageal Gliding Performance for Solid Oral Dosage Forms

Pharmaceutics, 2020
Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system.
Nélio Drumond, Sven Stegemann
doaj   +1 more source