Results 81 to 90 of about 2,441,236 (286)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Successful Treatment of an Angiosarcoma of the Nose with Radiation Therapy

Case Reports in Oncology, 2012
Angiosarcoma is a rare, aggressive malignancy of endothelial cells lining blood vessels. It poses therapeutic challenges since there is no standard established treatment.
Vatsal B. Patel, Tod W. Speer
doaj   +1 more source

Mechanisms and Evidence-Based Advantages of Traditional Chinese Medicine Wax Therapy in Chronic Disease Treatment

Journal of Contemporary Medical Practice
Objective: To systematically elaborate the core mechanisms of Traditional Chinese Medicine (TCM) wax therapy in treating chronic diseases and provide evidence-based support for its standardized clinical application. Methods: Databases including CNKI, PubMed, and Web of Science (2010-2024) were searched to include clinical studies, basic experiments ...
Jian Song, Jing Yuan, Kaiqiang Meng
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Implant-supported overdenture, an alternative option for the rehabilitation of a completely edentulous mandibular arch

Journal of Oral Research and Review
Edentulism has been a long-standing concern in prosthodontics. Several of the drawbacks of conventional denture therapy have been observed to be addressed by implant therapy nowadays.
Ganesh Ram Kumar Rajapandi, Ahila Singaravel Chidambaranathan, Muthukumar Balasubramaniam   +2 more
doaj   +1 more source

A CASE REPORT FOR PHYSIOTHERAPY PROGRAM IN ADULTHOOD PATIENTS WITH IDIOPATHIC CERVICAL SCOLIOSIS – ANALYSIS AND RESULTS [PDF]

Journal of IMAB
When scoliosis is inadequately treated during childhood and adolescence, it persists into adulthood, often contributing to more pronounced degeneration of the intervertebral discs and more severe pain.
Radostina Madzharova, Maya Krastanova, Irena Stoilova, Viktor Mikson, Emil Simeonov   +4 more
doaj   +1 more source

776 Use of Paraffin Wax During Occupational Therapy Treatment of Burn Survivors

Journal of Burn Care & Research
Abstract Introduction Burn survivors face long and often painful rehabilitation after injury. Unfortunately, the severe pain from burn injuries can lead to chronic pain and stress-related disorders.
openaire   +1 more source