Results 31 to 40 of about 1,712,433 (287)

ON \(\lambda\)-WEAK CONVERGENCE OF SEQUENCES DEFINED BY AN ORLICZ FUNCTION

Ural Mathematical Journal
In this article, we introduce and rigorously analyze the concept of difference \(\lambda\)-weak convergence for sequences defined by an Orlicz function.
Ömer Kişi, Mehmet Gürdal
doaj   +1 more source

Joint Discrete Approximation of Analytic Functions by Shifts of the Riemann Zeta-Function Twisted by Gram Points

Mathematics, 2023
Let θ(t) denote the increment of the argument of the product π−s/2Γ(s/2) along the segment connecting the points s=1/2 and s=1/2+it, and tn denote the solution of the equation θ(t)=(n−1)π, n=0,1,…. The numbers tn are called the Gram points. In this paper,
Antanas Laurinčikas
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Weak convergence theorem for Passty type asymptotically nonexpansive mappings

International Journal of Mathematics and Mathematical Sciences, 1999
In this paper, we prove a convergence theorem for Passty type asymptotically nonexpansive mappings in a uniformly convex Banach space with Fréchet-differentiable norm.
B. K. Sharma, B. S. Thakur, Y. J. Cho
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Short Communication: On the Weak Convergence Rate in the Discretization of Rough Volatility Models

, 2022
We study the weak convergence rate in the discretization of rough volatility models. After showing a lower bound 2H under a general model, where H is the Hurst index of the volatility process, we give a sharper bound H+1/2 under a linear ...
Bayer, Christian, Fukasawa, Masaaki, Nakahara, Shonosuke, Shonosuke Nakahara, Christian Bayer, Masaaki Fukasawa   +5 more
core   +1 more source