Results 41 to 50 of about 1,712,433 (287)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Weak Convergence of Robust Functions on Topological Groups

Mathematics
This paper introduces weak variants of level convergence (L-convergence) and epigraph convergence (E-convergence) for nets of level functions on general topological spaces, extending the classical metric and real-valued frameworks to ordered codomains ...
Víctor Ayala, Heriberto Román-Flores, Adriano Da Silva   +2 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Generalized Convergence for Multi-Step Schemes under Weak Conditions

Mathematics
We have developed a local convergence analysis for a general scheme of high-order convergence, aiming to solve equations in Banach spaces. A priori estimates are developed based on the error distances.
Ramandeep Behl, Ioannis K. Argyros, Hashim Alshehri, Samundra Regmi   +3 more
doaj   +1 more source

On weak and strong convergence theorems for a finite family of nonself I-asymptotically nonexpansive mappings [PDF]

Mathematica Moravica, 2015
We prove the weak and strong convergence of S iterative scheme to a common fixed point of a family of nonself asymptotically I-nonexpansive mappings {Ti}Ni i and a family of nonself asymptotically nonexpansive mappings {Ii}Ni i defined on a nonempty ...
Gündüz Birol, Akbulut Sezgin
doaj  

Mean and weak convergence of some orthogonal Fourier expansions by using Ap theory [PDF]

, 1989
Lp convergence of Fourier expansions in orthogonal polynomials is studied for general (but around the endpoints Jacobi-like) weights of orthogonality. The authors observe that the problem is related to Muckenhoupt's Ap conditions.
Varona Malumbres, Juan Luis [0000-0002-2023-9946], Pérez, M. [0000-0002-3050-3712], Guadalupe Hernández, José Javier   +2 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Submartingale condition for weak convergence for semi-Markov processes

Modern Stochastics: Theory and Applications
In this paper, we consider a modified version of a well-known submartingale condition for the weak convergence of probability measures, adapted to the semi-Markov case.
Vitaliy Golomoziy
doaj   +1 more source