Results 51 to 60 of about 166,071,484 (282)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Relative Entropy and Variational Properties of Generalized Gibbsian Measures [PDF]

, 2004
We study the relative entropy density for generalized Gibbs measures. We first show its existence and obtain a familiar expression in terms of entropy and relative energy for a class of “almost Gibbsian measures” (almost sure continuity of conditional ...
Ny, Arnaud Le,, Külske, Christof, Redig, F.H.J., Le Ny, Arnaud, Redig, Frank,, Redig, FHJ Frank, Le Ny, A., Redig, Frank, Külske, C., Külske, Christof,, Le Ny, A, Külske, C, Ny, Arnaud Le   +12 more
core   +2 more sources

A Discrete Limit Theorem for L-Functions of Elliptic Curves

Jaunųjų Mokslininkų Darbai, 2018
In the paper, we prove the discrete limit theorem in the sense of the weak convergence of probability measures in the space of analytic on DV = {s ∈ C : 1 < σ < 3/2, |t|  0 be a fixed real number such that exp {2πk/h} is an irrational number for all k∈Z\{
Virginija Garbaliauskienė, Antanas Garbaliauskas   +1 more
doaj   +1 more source

Weak integral convergence theorems and operator measures [PDF]

Pacific Journal of Mathematics, 1984
In the first part of this paper (submitted in 1978 and revised in 1983), an integration theory is outlined for (certain measurable) functions with values in a locally convex (l.c.) space X with respect to a measure \(\mu\) with values in the continuous linear operators L(X,Y) from X into some (quasi-complete) l.c. space Y such that \(\mu\) (\(\cdot)x\)
Smith, William V., Tucker, Don H.
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Joint approximation of analytic functions by the shifts of Hurwitz zeta-functions in short intervals

Open Mathematics
In the article, we obtain that, for algebraically independent over Q{\mathbb{Q}} parameters α1,…,αr{\alpha }_{1},\ldots ,{\alpha }_{r}, there are infinitely many shifts (ζ(s+iτ,α1),…,ζ(s+iτ,αr))\left(\zeta \left(s+i\tau ,{\alpha }_{1}),\ldots ,\zeta ...
Laurinčikas Antanas, Šiaučiūnas Darius   +1 more
doaj   +1 more source

Discrete Limit Bohr–Jessen Type Theorem for the Epstein Zeta-Function in Short Intervals

Axioms
We prove a probabilistic limit theorem for the Epstein zeta-function ζ(s;Q) in the interval [N,N+M] as N→∞, using discrete shifts ζ(σ+ikh;Q), where h>0 and σ>n−12 are fixed. Here, Q is a positive-definite n×n matrix, and the interval length M satisfies h−
Antanas Laurinčikas, Renata Macaitienė
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

On Value Distribution of One Epstein Zeta-Function

Mathematics
The paper is devoted to Epstein zeta-function ζ3(s), s=σ+it, of a quadratic form of three variables. We obtain a probabilistic characterization of the function ζ3(s) in terms of weak convergence of probability measures in the space of analytic functions ...
Kalyan Chakraborty, Antanas Laurinčikas
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source