Results 51 to 60 of about 417,817 (243)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Characterization of Weak Magnetic Internal Detection Signals of Hard Spot Defects in Long-Distance Oil and Gas Pipelines

Magnetochemistry
A hard spot defect refers to structural defects that occur in long-distance oil and gas pipelines during the thermal processes. These defects arise from the combination of material phase changes and stress concentration, making them challenging to detect.
Jiawen Zhang, Chisen Qin, Nan Liu, Zheng Lian, Guangwen Sun, Bin Liu, Lijian Yang   +6 more
doaj   +1 more source

On deformations of quasi-Miura transformations and the Dubrovin-Zhang bracket

, 2011
In our recent paper we proved the polynomiality of a Poisson bracket for a class of infinite-dimensional Hamiltonian systems of PDE's associated to semi-simple Frobenius structures.
A. Buryak, Dubrovin, Eguchi, Givental, Givental, H. Posthuma, Kontsevich, Kontsevich, Lee, S. Shadrin, Shadrin   +10 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Benchmarking E-Government: Global Trends and Digital Divide

Статистика України
E-Government, being a basic component in the public administration, is a crucial factor in setting up information communications between various branches of the state power and in ensuring access of community and business to public services in online ...
А. М. Yerina
doaj   +1 more source

Spike-timing computation properties of a feed-forward neural network model

Frontiers in Computational Neuroscience, 2014
Brain function is characterized by dynamical interactions among networks of neurons. These interactions are mediated by network topology at many scales ranging from microcircuits to brain areas.
Drew Benjamin Sinha, Noah M Ledbetter, Dennis L Barbour   +2 more
doaj   +1 more source

Homotopy (Pre-)Derivators of Cofibration Categories and Quasi-Categories

, 2018
We prove that the homotopy prederivator of a cofibration category is equivalent to the homotopy prederivator of its associated quasi-category of frames, as introduced by Szumi\l{}o.
Lenz, Tobias
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Divergent dynamics of surface water patterns and structures in Europe's coastal-zone basins

Ecological Informatics
Surface water bodies are essential components of terrestrial ecosystems and play critical roles in sustainable development. Coastal-zone basins (CZBs), shaped by human activity and land–sea interactions, have undergone rapid urban expansion, landscape ...
Liumeng Chen, Yongchao Liu, Jialin Li, Chao Ying, Peng Tian, Wenfei Kuang, Qiyu Huang, Tian Zheng   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source