Results 41 to 50 of about 46,236 (223)
Anticipatory governance and leadership for AI implementation in higher education: A scoping review
International Journal of Educational Technology in Higher EducationAs the education sector attempts to address rapid changes caused by Artificial Intelligence (AI), it becomes crucial to examine approaches to leadership at the organizational and system levels.
Sandra Baroudi
doaj +1 more source
Spike-timing computation properties of a feed-forward neural network model
Frontiers in Computational Neuroscience, 2014 Brain function is characterized by dynamical interactions among networks of neurons. These interactions are mediated by network topology at many scales ranging from microcircuits to brain areas.
Drew Benjamin Sinha +2 more
doaj +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Diagnosing atmosphere–land feedbacks in CMIP5 climate models
Environmental Research Letters, 2012 Human-made transformations to the environment, and in particular the land surface, are having a large impact on the distribution (in both time and space) of rainfall, upon which all life is reliant.
C J R Williams, R P Allan, D R Kniveton
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
International Journal of ThermofluidsThe increasing demand for sustainable and long-lasting energy sources has highlighted the limitations of conventional flat plate collectors (FPCs), particularly their reduced efficiency under low solar radiation and weak fluid heat transfer capabilities.
T. Sathish, A. Johnson Santhosh
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source