Results 51 to 60 of about 46,236 (223)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

WAYS OF IMPLEMENTING A COMPLEX APPROACH TO INCREASE THE COMPETITIVENESS OF UKRAINE [PDF]

European Vector of Economic Development
The study focuses on examining the key factors influencing the competitive state of Ukraine’s socio-economic model at the current stage of development.
Alisa S. Mahdich, Oleksandr A. Zadoia, Artem M. Novikov   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Elderly People’s Perceptions of Change after Urban Regeneration: A Comparison of Istanbul Neighborhoods

Senectus
This study investigates the social effects of urban regeneration, exploring how cities that have undergone historical changes and transformations are dealing with this phenomenon today.
Furkan Başarslan
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Scattering from (p, q)-strings in AdS5 × S5

Journal of High Energy Physics
Motivated by understanding the scattering of gravitons and their superpartners from extended (p, q)-strings in type IIB string theory via AdS/CFT, we study an integrated two-point function of stress tensor multiplet operators in the presence of a half ...
Silviu S. Pufu, Victor A. Rodriguez, Yifan Wang   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

ICT-Net: A Framework for Multi-Domain Cross-View Geo-Localization with Multi-Source Remote Sensing Fusion

Remote Sensing
Traditional single neural network-based geo-localization methods for cross-view imagery primarily rely on polar coordinate transformations while suffering from limited global correlation modeling capabilities.
Min Wu, Sirui Xu, Ziwei Wang, Jin Dong, Gong Cheng, Xinlong Yu, Yang Liu   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

MHD triple diffusion due to the impulsive flow of micropolar nanofluids around a cone: Mangler's transformations and ANN analyses

Propulsion and Power Research
An implicit finite difference (FD) and artificial neural network (ANN) techniques are applied to study the triple diffusion and non-linear mixed convection flow around a vertical cone.
Z.Z. Rashed, Sameh E. Ahmed
doaj   +1 more source