Results 81 to 90 of about 528,108 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Investigating the Coherence Between Motor Cortex During Rhythmic Finger Tapping Using OPM-MEG

open access: yesPhotonics
Optically pumped magnetometer OPM-MEG has the potential to replace the traditional low-temperature superconducting quantum interference device SQUID-MEG.
Hao Lu   +4 more
doaj   +1 more source

On Weak Compactness in Spaces of Measures

open access: yesJournal of Functional Analysis, 1997
It is proved that a weak\(^*\) compact subset \(A\) of scalar measures on a \(\sigma\)-algebra is weakly compact if and only if there exists a nonnegative scalar measure \(\lambda\) such that each measure in \(A\) is \(\lambda\)-continuous (such a measure \(\lambda\) is called a control measure for \(A\)).
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Measuring Phase–Amplitude Coupling Effect with OPM-MEG

open access: yesPhotonics
Optically pumped magnetometers (OPMs) present a promising opportunity to advance magnetoencephalography (MEG), enhancing the accuracy of neuronal activity recordings due to their high spatiotemporal resolution.
Yong Li   +7 more
doaj   +1 more source

Weak-measurement-induced heating in Bose-Einstein condensates. [PDF]

open access: yesPhys Rev Res, 2023
Altuntaş E, Spielman IB.
europepmc   +1 more source

Weak values beyond weak measurement

open access: yes, 2013
5 pages, 2 figures, v2 updated to address anonymous and friendly ...
openaire   +2 more sources

Home - About - Disclaimer - Privacy