Results 61 to 70 of about 882,940 (266)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Twisted Weak Orders of Coxeter Groups [PDF]
Order, 2019 In this paper, we initiate the study of the twisted weak order associated to a twisted Bruhat order for a Coxeter group and explore the relationship between the lattice property of such order and the infinite reduced words. We show that for a 2 closure biclosed set $B$ in $Φ^+$, the $B$-twisted weak order is a non-complete meet semilattice if $B$ is ...
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Improved Fractional-order Damping Method for Voltage-controlled DFIG System Under Weak Grid
Journal of Modern Power Systems and Clean Energy, 2022 When a doubly-fed induction generator (DFIG) is connected to a weak grid, the coupling between the grid and the DFIG itself will increase, which will cause stability problems. It is difficult to maintain the tracking accuracy and ro-bustness of the phase-
Zhen Xie +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Effects of Second-Order Matched Stochastic Resonance for Weak Signal Detection
IEEE Access, 2018 Weak signal detection via stochastic resonance (SR) has attracted considerable attention in a wide range of research fields, especially under heavy background noise circumstances.
Haitao Dong +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Characterizations of the Weak Bivariate Failure Rate Order and Bivariate IFR Aging Class
Journal of Mathematics, 2022 In this paper, two characterizations of the weak bivariate failure rate order over the bivariate Laplace transform order of two-dimensional residual lifetimes are given.
M. Kayid
doaj +1 more source