Results 71 to 80 of about 882,940 (266)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Ball Comparison for Some Efficient Fourth Order Iterative Methods Under Weak Conditions

open access: yesMathematics, 2019
We provide a ball comparison between some 4-order methods to solve nonlinear equations involving Banach space valued operators. We only use hypotheses on the first derivative, as compared to the earlier works where they considered conditions reaching up ...
Ioannis K. Argyros, Ramandeep Behl
doaj   +1 more source

Wachs permutations, Bruhat order and weak order

open access: yesEuropean Journal of Combinatorics
We study the partial orders induced on Wachs and signed Wachs permutations by the Bruhat and weak orders of the symmetric and hyperoctahedral groups. We show that these orders are graded, determine their rank function, characterize their ordering and covering relations, and compute their characteristic polynomials, when partially ordered by Bruhat ...
Brenti, Francesco, Sentinelli, Paolo
openaire   +3 more sources

Weak selections and weak orderability of function spaces [PDF]

open access: yesCzechoslovak Mathematical Journal, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Weak-Foci of High Order and Cyclicity [PDF]

open access: yesQualitative Theory of Dynamical Systems, 2016
A particular version of the 16th Hilbert's problem is to estimate the number, M(n), of limit cycles bifurcating from a singularity of center-focus type. This paper is devoted to finding lower bounds for M(n) for some concrete n by studying the cyclicity of different weak-foci.
Haihua Liang, Joan Torregrosa
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Ball Convergence of an Efficient Eighth Order Iterative Method Under Weak Conditions

open access: yesMathematics, 2018
The convergence order of numerous iterative methods is obtained using derivatives of a higher order, although these derivatives are not involved in the methods.
Janak Raj Sharma   +2 more
doaj   +1 more source

Partial orders generalizing the weak order on Coxeter groups

open access: yesJournal of Combinatorial Theory, Series A, 2003
Taking a Coxeter system of type \(M\) to be a pair \((W,R)\), with Wa group generated by \(\{\Gamma_i\}^n_{i=1}=R\) and \(M=(M_{ij})\) a symmetric matrix with \(M_{ii}=1\), \(M_{ij}\in N\), \((\Gamma_i\Gamma_j)^{Mij}=1\), these systems have been investigated from different perspectives since the generators \(\Gamma_i\) with \(\Gamma_i^2=e\), may be ...
Curtis D. Bennett, Rieuwert J. Blok
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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