Results 91 to 100 of about 1,205,866 (291)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The power of weak signals: how systematic reviews direct researchers away from potentially biased primary studies. [PDF]

Cochrane Database Syst Rev, 2022
Salandra R, Criscuolo P, Salter A.
europepmc   +1 more source

Wild cards, weak signals and prganizational improvisation [PDF]

This paper addresses the need for reliable action guidelines that can be used by organisations in turbulent environments. Building on current conceptual and empirical research, we suggest an analytical approach for the management of surprising and ...
Cunha, Miguel Pina e, Kaivo-oja, Jari, Mendonca, Sandro, Ruff, Frank   +3 more
core  

Weak temporal signals can synchronize and accelerate the transition dynamics of biopolymers under tension

, 2012
In addition to thermal noise, which is essential to promote conformational transitions in biopolymers, cellular environment is replete with a spectrum of athermal fluctuations that are produced from a plethora of active processes.
Bell, Bustamante, C. Hyeon, Cecconi, Doering, Dudko, Gammaitoni, Hyeon, H  nggi, Kim, Liphardt, McDonnell, Onoa, Onuchic, Pizzolato, Sanchez, Shaevitz, Shin, Smith, Stigler, Strick, Thirumalai, Visscher, W. K. Kim, W. Sung, Wen, Woodside, Zhou   +27 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Adaptive Low-Rank Tensor Estimation Model Based Multichannel Weak Fault Detection for Bearings

Sensors
Multichannel signals contain an abundance of fault characteristic information on equipment and show greater potential for weak fault characteristics extraction and early fault detection.
Huiming Jiang, Yue Wu, Jing Yuan, Qian Zhao, Jin Chen   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Fusion Filtering‐Based Method for Extracting Spectral Trajectories of Non‐Repetitive Transient Weak Signals in Multiple Frequency Bands for Industrial Control Networks

Engineering Reports
In response to the problem of difficulty in accurately extracting spectral trajectories of multi‐band non‐repetitive transient weak signals in industrial control networks under strong noise background, this paper proposes a method that introduces a ...
Changzhong Gao, Zhenyong Yang, Yong Wang, Hailong Meng, Jidong Lei   +4 more
doaj   +1 more source

Line-Defect Phononic Crystal Structure for Directional Enhancement Detection of Weak Acoustic Signals

Crystals
Effective detection of acoustic signals plays a crucial role in numerous fields, including industrial equipment fault prediction and environmental monitoring.
Shijie Zhang, Jinling Mu, Jiawei Xiao, Huiqiang Xu   +3 more
doaj   +1 more source