Results 111 to 120 of about 8,223,685 (372)

Weak Underwater Signals’ Detection by the Unwrapped Instantaneous Phase

Journal of Marine Science and Engineering
In marine seismic surveys, weak signals can be overlaid by stronger signals or even random noise. Detecting these signals can be challenging, especially when they are close to each other or partially overlapping.
Aldo Vesnaver, Luca Baradello, Eleonora Denich   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The power of weak signals: how systematic reviews direct researchers away from potentially biased primary studies. [PDF]

Cochrane Database Syst Rev, 2022
Salandra R, Criscuolo P, Salter A.
europepmc   +1 more source

Weak warning signals can persist in the absence of gene flow

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance With our comprehensive set of field (model survival), laboratory (controlled learning, palatability, toxin analysis), and molecular data, we provide evidence that polymorphism can persist in an aposematic population, despite expectations of ...
J. Lawrence, Bibiana Rojas, Antoine Fouquet, J. Mappes, Annelise Blanchette, R. Saporito, R. J. Bosque, Elodie A. Courtois, B. Noonan   +8 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adaptive Low-Rank Tensor Estimation Model Based Multichannel Weak Fault Detection for Bearings

Sensors
Multichannel signals contain an abundance of fault characteristic information on equipment and show greater potential for weak fault characteristics extraction and early fault detection.
Huiming Jiang, Yue Wu, Jing Yuan, Qian Zhao, Jin Chen   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Fusion Filtering‐Based Method for Extracting Spectral Trajectories of Non‐Repetitive Transient Weak Signals in Multiple Frequency Bands for Industrial Control Networks

Engineering Reports
In response to the problem of difficulty in accurately extracting spectral trajectories of multi‐band non‐repetitive transient weak signals in industrial control networks under strong noise background, this paper proposes a method that introduces a ...
Changzhong Gao, Zhenyong Yang, Yong Wang, Hailong Meng, Jidong Lei   +4 more
doaj   +1 more source

Line-Defect Phononic Crystal Structure for Directional Enhancement Detection of Weak Acoustic Signals

Crystals
Effective detection of acoustic signals plays a crucial role in numerous fields, including industrial equipment fault prediction and environmental monitoring.
Shijie Zhang, Jinling Mu, Jiawei Xiao, Huiqiang Xu   +3 more
doaj   +1 more source