Results 91 to 100 of about 8,223,685 (372)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Megatrends and weak signals shaping future real estate

Buildings & Cities
Society prepares for an envisioned future by shaping that future to align with current perceptions. This paper explores real estate market participants’ (n ≥ 840) perceptions of various forces influencing the future of housing, retail and office spaces ...
Saija Toivonen
doaj   +1 more source

Weak Molecular Interactions in Organic Composite Dry Film Lead to Degradable, Robust Wireless Electrophysiological Signal Sensing (Adv. Mater. Interfaces 24/2022) [PDF]

, 2022
Taehyun Park, Jin-Woo Jeong, Young‐Joon Kim, Hocheon Yoo   +3 more
openalex   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The test case of HD26965: difficulties disentangling weak Doppler signals from stellar activity

, 2018
We report the discovery of a radial velocity signal that can be interpreted as a planetary-mass candidate orbiting the K dwarf HD26965, with an orbital period of 42.364$\pm$0.015 days, or alternatively, as the presence of residual, uncorrected rotational
Arriagada, Pamela, Butler, R. Paul, Crane, Jeffrey D., Díaz, Matías R., Feng, Fabo, Jenkins, James S., Shectman, Stephen A., Soto, Maritza G., Teske, Johanna K., Thompson, Ian B., Tuomi, Mikko, Vogt, Steven S.   +11 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Non-Gaussianity analysis of GW background made by short-duration burst signals

, 2009
We study an observational method to analyze non-Gaussianity of a gravitational wave (GW) background made by superposition of weak burst signals. The proposed method is based on fourth-order correlations of data from four detectors, and might be useful to
G. B. Rybicki, K. S. Thorne, Naoki Seto   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Weak Signal Enhance Based on the Neural Network Assisted Empirical Mode Decomposition

Sensors, 2020
In order to enhance weak signals in strong noise background, a weak signal enhancement method based on EMDNN (neural network-assisted empirical mode decomposition) is proposed.
Kai Chen, Kai Xie, Chang Wen, Xin-Gong Tang   +3 more
doaj   +1 more source

Amplification by stochastic interference

, 1996
A new method is introduced to obtain a strong signal by the interference of weak signals in noisy channels. The method is based on the interference of 1/f noise from parallel channels.
Chaitin G J, Chaitin G J, D Felix, Ehrenberger K, Falconer K J, Hamming R W, K Ehrenberger, K Svozil, King C C, Kolmogorov A N, Liebovitch L S, Maddox J, Martin-Löf P, Martin-Löf P, Martin-Löf P, Schnorr C P, Svozil K, Teich M C, van der Ziel A, Voss R F   +19 more
core   +2 more sources