Results 101 to 110 of about 1,205,866 (291)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Information Design for “Weak Signal” detection and processing in Economic Intelligence: A case study on Health resources [PDF]

Journal of Intelligence Studies in Business, 2011
The topics of this research cover all phases of “Information Design” applied to detect and profit from weak signals in economic intelligence (EI) or business intelligence (BI).
Sahbi Sidhom, Philippe Lambert
doaj  

Partly Duffing Oscillator Stochastic Resonance Method and Its Application on Mechanical Fault Diagnosis

Shock and Vibration, 2016
Due to the fact that the slight fault signals in early failure of mechanical system are usually submerged in heavy background noise, it is unfeasible to extract the weak fault feature via the traditional vibration analysis.
Jian Dang, Rong Jia, Xingqi Luo, Hua Wu, Diyi Chen   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Information capacity in the weak-signal approximation [PDF]

Physical Review E, 2010
We derive an approximate expression for mutual information in a broad class of discrete-time stationary channels with continuous input, under the constraint of vanishing input amplitude or power. The approximation describes the input by its covariance matrix, while the channel properties are described by the Fisher information matrix.
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A New Chaotic Weak Signal Detection Method Based on a Simplified Fractional-Order Genesio–Tesi Chaotic System

Fractal and Fractional
The detection of weak signals is a well-established application in chaos theory. This theory leverages the inherent robustness of chaotic systems, enabling them to resist noise and thus serve as effective tools for identifying weak signals.
Hongcun Mao, Yuling Feng, Xiaoqian Wang, Chao Gao, Changhao Lin, Zhihai Yao   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Blind separation of asymmetric PCMA signal based on soft information joint correction

Tongxin xuebao, 2017
On the basis of a blind separation structure with low complexity,an efficient blind separation algorithm based on soft information joint correction was proposed for asymmetric PCMA to improve the demodulation performance of strong and weak signals.By ...
Qiang HUANG, Hua PENG, Tian-yun LI, Ke-xian GONG   +3 more
doaj   +2 more sources

A Novel Blind Source Separation Algorithm and Performance Analysis of Weak Signal against Strong Interference in Passive Radar Systems

International Journal of Antennas and Propagation, 2016
In Passive Radar System, obtaining the mixed weak object signal against the super power signal (jamming) is still a challenging task. In this paper, a novel framework based on Passive Radar System is designed for weak object signal separation.
Chengjie Li, Lidong Zhu, Anhong Xie, Zhongqiang Luo   +3 more
doaj   +1 more source