Results 51 to 60 of about 4,951 (263)

Noncommutativity and the weak cosmic censorship

Journal of High Energy Physics, 2019
We show that a noncommutative massless scalar probe can dress a naked singularity in AdS3 spacetime, consistent with the weak cosmic censorship. The dressing occurs at high energies, which is typical at the Planck scale.
Kumar S. Gupta, Tajron Jurić, Andjelo Samsarov, Ivica Smolić   +3 more
doaj   +1 more source

A mathematical model for the use of energy resources: a singular parabolic equation

Mathematical Modelling and Analysis, 2020
We consider a singular parabolic equation, for , arising in symmetric boundary layer flows. Here is a bounded domain with C2 boundary is bounded, and T > 0 is some fixed time.
Daniel López-García, Rosa Pardo
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Gravitational Collapse and Singularity Removal in Rastall Theory

Advances in High Energy Physics, 2021
In the present work, we study spherically symmetric gravitational collapse of a homogeneous fluid in the framework of Rastall gravity. Considering a nonlinear equation of state (EoS) for the fluid profiles, we search for a class of nonsingular collapse ...
Ehsan Dorrani
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Null weak singularities in plane-symmetric space-times [PDF]

Physical Review D, 1998
We construct a new class of plane-symmetric solutions possessing a curvature singularity which is null and weak, like the spacetime singularity at the Cauchy horizon of spinning (or charged) black holes. We then analyse the stability of this singularity using a rigorous non-perturbative method.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Anisotropic singularity of solutions to elliptic equations in a measure framework

Electronic Journal of Differential Equations, 2015
In this article we study the weak solutions of elliptic equation $$\displaylines{ -\Delta u=2\frac{\partial \delta_0}{\partial \nu }\quad \text{in }\Omega,\cr u=0\quad \text{on }\partial\Omega, }$$ where $\Omega$ is an open bounded $C^2$ domain ...
Wanwan Wang, Huyuan Chen, Jian Wang
doaj  

Gravitational perfect fluid collapse in Gauss–Bonnet gravity

European Physical Journal C: Particles and Fields, 2017
The Einstein Gauss–Bonnet theory of gravity is the low-energy limit of heterotic super-symmetric string theory. This paper deals with gravitational collapse of a perfect fluid in Einstein–Gauss–Bonnet gravity by considering the Lemaitre–Tolman–Bondi ...
G. Abbas, M. Tahir
doaj   +1 more source